{"id":"W2802569467","doi":"10.1172/jci.insight.98240","title":"Cystic fibrosis–related diabetes is caused by islet loss and inflammation","year":2018,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Johns Hopkins University; National Institutes of Health; Leona M. and Harry B. Helmsley Charitable Trust; Vanderbilt University; Cystic Fibrosis Foundation","keywords":"Islet; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Inflammation; Internal medicine; Endocrinology; Cystic fibrosis-related diabetes; Diabetes mellitus; Pancreas; Pancreatic islets; Fibrosis; Medicine; Enteroendocrine cell; Biology; Insulin resistance; Endocrine system; Impaired glucose tolerance; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001907659,0.0003765435,0.0003256382,0.0003830982,0.0002438728,0.0004389995,0.000102288,0.0002720514,0.00143521],"category_scores_gemma":[0.0001976599,0.0001320543,0.0001999578,0.0002668554,0.0004321863,0.0002593038,0.0003195285,0.0005839861,0.0002673403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000175148,"about_ca_system_score_gemma":0.0001473421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002562941,"about_ca_topic_score_gemma":0.0003289814,"domain_scores_codex":[0.9998255,0.00002672604,0.00001611992,0.00004287386,0.00005449607,0.00003434216],"domain_scores_gemma":[0.999833,0.00002442487,0.00006330885,0.00001793147,0.00001221429,0.00004915019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003773582,0.00007693164,0.01459337,0.0002131541,0.00003001204,0.002243613,0.0000893955,0.00005878303,0.9615365,0.0005464462,0.0005941047,0.0196403],"study_design_scores_gemma":[0.0001211644,0.001638837,0.4033607,0.0002103032,0.0001679322,0.06814131,0.0005158306,0.0008994363,0.4787424,0.001511472,0.04464339,0.00004716713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754227,0.01187792,0.003752525,0.0005018759,0.0001660114,0.00004550525,0.0004015945,0.0001617802,0.007670064],"genre_scores_gemma":[0.9876906,0.007372777,0.002050906,0.0003398641,0.00008983303,0.00002169297,0.0003372943,0.00002560202,0.002071527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143521,"threshold_uncertainty_score":0.004801273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007790778678200593,"score_gpt":0.2260138739800263,"score_spread":0.2182230953018257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}