{"id":"W2802571577","doi":"10.1073/pnas.1720719115","title":"Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Peripheral blood mononuclear cell; Transcriptome; Circadian rhythm; Peripheral; Peripheral blood; Medicine; Biology; Immunology; Neuroscience; Internal medicine; Gene; In vitro; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006923739,0.0001397758,0.0001886154,0.0001393076,0.000508345,0.00003997066,0.001408494,0.0001216006,0.00007777069],"category_scores_gemma":[0.0002144659,0.00008676063,0.0001444814,0.001320906,0.002397262,0.0003624703,0.000114097,0.000234198,0.000002507385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003045694,"about_ca_system_score_gemma":0.00004934546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008859581,"about_ca_topic_score_gemma":1.031062e-7,"domain_scores_codex":[0.9976087,0.00002207856,0.0004247402,0.0003648842,0.001314082,0.0002655211],"domain_scores_gemma":[0.9992123,0.00008901594,0.0004807028,0.00002459642,0.0001239402,0.00006947434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009650769,0.00009669609,0.005517201,0.00003028787,0.000006161742,1.256759e-8,0.002396145,0.00006805766,0.963598,0.02808658,0.0001575911,0.00003364502],"study_design_scores_gemma":[0.0002694567,0.00007141188,0.08346486,0.00008929649,0.00001831902,0.000002908926,0.0001269925,0.00007415147,0.9091005,0.006396637,0.0002886247,0.00009687852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841176,0.00007696534,1.499552e-7,0.001907191,0.00006491238,0.0002614106,0.00001429138,0.00001442352,0.0135431],"genre_scores_gemma":[0.9988512,0.000007241696,0.00006312521,0.0005054315,0.000117175,0.000003441106,2.697741e-8,0.000008913094,0.0004434795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07794766,"threshold_uncertainty_score":0.8832811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04164718860261334,"score_gpt":0.2825619342332752,"score_spread":0.2409147456306619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}