{"id":"W2802575274","doi":"10.18632/oncotarget.25123","title":"Somatic mutations in early onset luminal breast cancer","year":2018,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"MUTYH; Germline mutation; Breast cancer; Cancer research; MLH1; Frameshift mutation; Germline; Biology; CHEK2; CDKN2A; BAP1; Cancer; PALB2; Genetics; Medicine; Mutation; Gene; DNA repair; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001801071,0.0002086966,0.0002085466,0.0009098012,0.0002804186,0.0007220955,0.0002213069,0.0005045314,0.002529697],"category_scores_gemma":[0.0007310901,0.0001595021,0.0001529728,0.0006474868,0.0002173931,0.0001424547,0.0003584184,0.0003356114,0.0004382133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004018047,"about_ca_system_score_gemma":0.0002722727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001890864,"about_ca_topic_score_gemma":0.003084648,"domain_scores_codex":[0.9998416,0.00002003722,0.00001309879,0.00003073418,0.0000602434,0.00003433027],"domain_scores_gemma":[0.9997849,0.00005759718,0.00007499233,0.00001276543,0.00002917286,0.00004061742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001828583,0.0001840333,0.6111358,0.0005722577,0.0001544478,0.04312242,0.0005768274,0.001069513,0.09910878,0.002918632,0.01006627,0.2292624],"study_design_scores_gemma":[0.00008442161,0.0002383687,0.8483,0.0003211783,0.0001892991,0.1035576,0.0007610698,0.001509554,0.01147255,0.002182099,0.03134424,0.00003952952],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699575,0.01393203,0.0007134948,0.0008581368,0.0001256806,0.00003404987,0.0008650121,0.00006780583,0.01344611],"genre_scores_gemma":[0.9917638,0.004339382,0.0006657955,0.0001987327,0.00004709073,0.000008331524,0.0004464782,0.00001707261,0.002513364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002529697,"threshold_uncertainty_score":0.008462727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006672588775857876,"score_gpt":0.2619369527973738,"score_spread":0.2552643640215159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}