{"id":"W2802575274","doi":"10.18632/oncotarget.25123","title":"Somatic mutations in early onset luminal breast cancer","year":2018,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"MUTYH; Germline mutation; Breast cancer; Cancer research; MLH1; Frameshift mutation; Germline; Biology; CHEK2; CDKN2A; BAP1; Cancer; PALB2; Genetics; Medicine; Mutation; Gene; DNA repair; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006100393,0.00008970137,0.00008821407,0.00003673586,0.00005089471,0.00002086974,0.0001048288,0.00006705167,0.0001425583],"category_scores_gemma":[0.00002476013,0.00009324336,0.00003669244,0.00007382385,0.00008741653,0.000002680029,0.00004792244,0.00004855553,0.00007378909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003439109,"about_ca_system_score_gemma":0.0001601536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000602796,"about_ca_topic_score_gemma":0.002168271,"domain_scores_codex":[0.9993961,0.00001691365,0.0001371207,0.0001930109,0.00006551918,0.0001912756],"domain_scores_gemma":[0.999646,0.00001086863,0.00004118089,0.0001845175,0.00005486984,0.00006257012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001116001,0.0001579017,0.9174865,0.00001737141,0.0000403041,0.00001193885,0.0004276685,0.00007922859,0.0628702,0.00007551048,0.01743764,0.001284171],"study_design_scores_gemma":[0.0007464924,0.0002413512,0.9458639,0.0000282429,0.00001967045,0.0000295436,0.00007126016,0.0001786389,0.01751786,0.0004776628,0.03457406,0.0002513324],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973962,0.0002440657,0.0001076097,0.0004687447,0.0003093045,0.00009153081,0.0002231038,0.000005676664,0.001153794],"genre_scores_gemma":[0.9977928,0.0001022587,0.0004772002,0.0003921803,0.0007330309,0.00003573654,0.00008592898,0.00001547807,0.0003653216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04535234,"threshold_uncertainty_score":0.3802354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006672588775857876,"score_gpt":0.2619369527973738,"score_spread":0.2552643640215159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}