{"id":"W2802615151","doi":"10.1021/acs.langmuir.8b00928","title":"Role of Transmembrane Potential and Defects on the Permeabilization of Lipid Bilayers by Alamethicin, an Ion-Channel-Forming Peptide","year":2018,"lang":"en","type":"article","venue":"Langmuir","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Alamethicin; Lipid bilayer; Chemistry; Peptide; Transmembrane protein; Ion channel; Biophysics; Transmembrane channels; Ion; Membrane; Chromatography; Chemical engineering; Biochemistry; Organic chemistry; Voltage-gated ion channel; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002555044,0.0003507178,0.0002299342,0.0001603833,0.0001376584,0.0004199763,0.0002608854,0.0004312811,0.0004764877],"category_scores_gemma":[0.0005875906,0.0001973695,0.0001475216,0.0001290567,0.0005015917,0.0005625131,0.0002711251,0.0003874226,0.0001092724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001856713,"about_ca_system_score_gemma":0.0001195974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003038197,"about_ca_topic_score_gemma":0.000180226,"domain_scores_codex":[0.9998139,0.00004902085,0.00001684917,0.00003422259,0.00004470642,0.00004137942],"domain_scores_gemma":[0.9996499,0.0001464803,0.00008216545,0.00002260919,0.00004211559,0.00005690858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001341847,0.00001236659,0.0003042084,0.00002898178,0.000004345138,0.00007535001,0.00003665737,0.00007064066,0.998675,0.00005913004,0.000004274038,0.0005948345],"study_design_scores_gemma":[0.00001558082,0.0001746314,0.005582646,0.000007138954,0.00001400338,0.000204607,0.0001016312,0.001864869,0.9917212,0.00007798284,0.0002257757,0.00001005136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989812,0.0003300757,0.0003970641,0.00002302354,0.000004660961,0.000004643556,0.00003381503,0.00001258098,0.0002129215],"genre_scores_gemma":[0.9994567,0.000159405,0.0002230394,0.00001141014,0.000002237919,0.000004559556,0.00003637426,0.000005367696,0.0001008682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004764877,"threshold_uncertainty_score":0.001594007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006767811756493955,"score_gpt":0.2315581436277465,"score_spread":0.2247903318712525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}