{"id":"W2802617257","doi":"10.1186/s12885-018-4300-2","title":"Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma","year":2018,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research; China Scholarship Council; University of Alberta","keywords":"SOX2; Cancer research; Wnt signaling pathway; Stem cell; Cancer stem cell; CD44; Anaplastic large-cell lymphoma; Cell growth; Biology; Cell culture; Cancer cell; Flow cytometry; Chemistry; Cell; Molecular biology; Cell biology; Cancer; Immunology; Lymphoma; Signal transduction; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108744,0.0001865596,0.000273337,0.00005210592,0.0001512844,0.00001892429,0.0001137001,0.00007208127,0.00004908759],"category_scores_gemma":[0.00002903336,0.0000978036,0.00007483057,0.0002703104,0.0002257753,0.00009050602,0.00007578987,0.00006859651,0.00000424387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003008781,"about_ca_system_score_gemma":0.000241234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003220537,"about_ca_topic_score_gemma":0.009814383,"domain_scores_codex":[0.9988689,0.0001122955,0.0002131929,0.0002985891,0.0002715223,0.0002355381],"domain_scores_gemma":[0.9990987,0.0002852778,0.0001952412,0.0002163082,0.0001502593,0.00005421032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003395755,0.003800325,0.8575739,0.0004204992,0.0006574466,0.0000193378,0.01702074,0.00004266129,0.08406144,0.0004963232,0.002890601,0.02962092],"study_design_scores_gemma":[0.002200582,0.0002179769,0.501251,0.0002242455,0.00008789558,0.00000408872,0.0006072868,0.00007308639,0.4951083,0.00002698258,0.0001292802,0.00006922174],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966254,0.001300163,0.00006422715,0.0003101902,0.0002420159,0.0006732853,0.000100952,0.00001108828,0.0006727198],"genre_scores_gemma":[0.9985832,0.0001919962,0.00003913128,0.000244094,0.000159738,0.0001714856,0.00001112763,0.00001427087,0.0005849586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4110469,"threshold_uncertainty_score":0.5476656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136244591925035,"score_gpt":0.2611979577834391,"score_spread":0.2498355118641887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}