{"id":"W2802617257","doi":"10.1186/s12885-018-4300-2","title":"Oxidative stress enhances tumorigenicity and stem-like features via the activation of the Wnt/β-catenin/MYC/Sox2 axis in ALK-positive anaplastic large-cell lymphoma","year":2018,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Canadian Institutes of Health Research; China Scholarship Council; University of Alberta","keywords":"SOX2; Cancer research; Wnt signaling pathway; Stem cell; Cancer stem cell; CD44; Anaplastic large-cell lymphoma; Cell growth; Biology; Cell culture; Cancer cell; Flow cytometry; Chemistry; Cell; Molecular biology; Cell biology; Cancer; Immunology; Lymphoma; Signal transduction; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268599,0.0002235822,0.0002245568,0.0002992053,0.0001206265,0.0003167327,0.00009110553,0.0001818457,0.001203483],"category_scores_gemma":[0.00006392703,0.0001301524,0.0002273419,0.0001845101,0.0001667,0.00018104,0.0001357263,0.0004204768,0.0002343904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171541,"about_ca_system_score_gemma":0.0001322293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006057838,"about_ca_topic_score_gemma":0.001194279,"domain_scores_codex":[0.9998618,0.00003010047,0.00001746481,0.00002050217,0.00003612187,0.00003388527],"domain_scores_gemma":[0.9999375,0.000008465555,0.00001486677,0.000006371115,0.00000756362,0.00002522015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001366285,0.00005570795,0.0004300946,0.0000225344,0.000003778392,0.00006327702,0.0000225295,0.00001982872,0.9986464,0.00002954389,0.00002754471,0.000542091],"study_design_scores_gemma":[0.00005207972,0.001026975,0.03093653,0.000006648091,0.00003521837,0.0004311409,0.000169677,0.001219378,0.9635469,0.00008552375,0.00248338,0.000006642957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997736,0.00090098,0.0004724837,0.00005316154,0.00001317435,0.00001394414,0.0001513493,0.00002943103,0.0006294387],"genre_scores_gemma":[0.9976875,0.0004689001,0.0002992493,0.00002730263,0.000006038755,0.00001866653,0.0002262705,0.000005482755,0.00126054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203483,"threshold_uncertainty_score":0.004026055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136244591925035,"score_gpt":0.2611979577834391,"score_spread":0.2498355118641887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}