{"id":"W2802666386","doi":"10.1124/dmd.117.079640","title":"Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Cellular Protection and Transport of Methylated Arsenic Metabolites Differs between Human Cell Lines","year":2018,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Nuclear Physics; Office of Science; U.S. Department of Energy; Alberta Innovates; Queen's University; University of Alberta; Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"Metabolite; Chemistry; HEK 293 cells; HeLa; Cell culture; Vesicle; Membrane transport; Arsenic; Biochemistry; Cell; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004521032,0.0003747183,0.0008256894,0.0002948268,0.0002764511,0.00002093678,0.00008581477,0.0002062603,0.00003473472],"category_scores_gemma":[0.00001797733,0.0003078489,0.0001561402,0.0004275519,0.0003763314,0.0002787014,0.00001537356,0.0002552152,0.000003938193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001541127,"about_ca_system_score_gemma":0.00004079457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001459229,"about_ca_topic_score_gemma":0.00007564119,"domain_scores_codex":[0.997868,0.0001204234,0.0006659495,0.0005676008,0.0004149775,0.0003630219],"domain_scores_gemma":[0.9988793,0.00002843402,0.0002802293,0.000312732,0.0002449213,0.0002543579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000518262,0.000196589,0.002865671,0.0007088337,0.0001031436,0.00001225335,0.0008820942,2.411903e-7,0.9934647,0.0005574635,0.000007827499,0.0006829216],"study_design_scores_gemma":[0.002722754,0.000097588,0.179596,0.0002751079,0.0009009081,0.000001928509,0.0001893367,0.00004153773,0.8139899,0.0007133107,0.001167624,0.0003039042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915665,0.004042679,0.001848855,0.000238173,0.0001213614,0.00151666,0.0001680134,0.0001279715,0.0003698085],"genre_scores_gemma":[0.9958915,0.0002525173,0.001569513,0.0000345049,0.0003464503,0.00009246873,0.0006845597,0.00005354298,0.001074976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1794747,"threshold_uncertainty_score":0.9999374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009516603602351145,"score_gpt":0.2258269249057204,"score_spread":0.2163103213033692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}