{"id":"W2802666386","doi":"10.1124/dmd.117.079640","title":"Multidrug Resistance Protein 1 (MRP1/ABCC1)-Mediated Cellular Protection and Transport of Methylated Arsenic Metabolites Differs between Human Cell Lines","year":2018,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Nuclear Physics; Office of Science; U.S. Department of Energy; Alberta Innovates; Queen's University; University of Alberta; Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"Metabolite; Chemistry; HEK 293 cells; HeLa; Cell culture; Vesicle; Membrane transport; Arsenic; Biochemistry; Cell; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003256981,0.0002153652,0.0004668861,0.0006221985,0.0003270947,0.001085094,0.0002492936,0.0003734838,0.003993873],"category_scores_gemma":[0.0006633748,0.0003010098,0.0004574746,0.0006697563,0.0003061073,0.0005379261,0.0002671153,0.0005104467,0.001074345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005272105,"about_ca_system_score_gemma":0.0003535065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004818223,"about_ca_topic_score_gemma":0.003015688,"domain_scores_codex":[0.9996319,0.00009706621,0.00004104824,0.00007797117,0.00008133043,0.00007063307],"domain_scores_gemma":[0.9995911,0.0001156191,0.00005121571,0.00008482811,0.0001193988,0.00003790113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001955243,0.0000997669,0.01238241,0.0001190836,0.0001238234,0.0003631244,0.0005350739,0.0001819629,0.9765874,0.001073907,0.0006127138,0.00596545],"study_design_scores_gemma":[0.00009062036,0.0009938914,0.1474223,0.00002986616,0.0003034587,0.002979527,0.001257273,0.001926803,0.8288953,0.0005349297,0.01551629,0.00004988017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898177,0.002414757,0.002813653,0.000214232,0.00003786801,0.00002334235,0.001985051,0.000109431,0.002583899],"genre_scores_gemma":[0.9932556,0.0008913144,0.0006348728,0.00006815921,0.000008465293,0.00001867247,0.002487548,0.00004051995,0.002594848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004818223,"threshold_uncertainty_score":0.0133608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009516603602351145,"score_gpt":0.2258269249057204,"score_spread":0.2163103213033692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}