{"id":"W2802667264","doi":"10.1016/j.cell.2018.03.056","title":"FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":944,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Research Council; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; ALS Society of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Medical Research Council; Royal Society; Wellcome Trust; Fondation Brain Canada","keywords":"Biology; Methylation; Arginine; Chaperone (clinical); DNA methylation; Cell biology; Computational biology; Genetics; Biophysics; DNA; Amino acid; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006385397,0.00005332548,0.00005628982,0.00003126333,0.00004093166,0.000009282766,0.00003738617,0.00004107197,0.00004628165],"category_scores_gemma":[0.00001700867,0.00005306131,0.00001818148,0.00006244775,0.00004674451,0.000005387659,0.00002119203,0.00003088332,0.000006509889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005262405,"about_ca_system_score_gemma":0.00001790145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003522825,"about_ca_topic_score_gemma":0.00000670466,"domain_scores_codex":[0.9995861,0.00002302208,0.000102483,0.000141619,0.00006167876,0.00008510514],"domain_scores_gemma":[0.999665,0.000004611227,0.00004779018,0.0001282307,0.0001099549,0.00004440755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004338427,0.00005726243,0.00004562301,0.000006861458,0.00001293684,1.982229e-7,0.00008775793,0.000007084523,0.9970055,0.00000525841,0.001365092,0.001363097],"study_design_scores_gemma":[0.0005467198,0.000317444,0.0001103873,0.000003483454,0.000007181635,0.000001361258,0.00002746184,0.007731891,0.9871104,0.00001749391,0.004074714,0.00005151507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851406,0.0004028009,0.01345844,0.0001174171,0.00002515388,0.000097098,0.00001516022,0.000003609559,0.0007397896],"genre_scores_gemma":[0.9976198,0.00006654282,0.0003195557,0.00006922677,0.00003942639,0.000006674201,0.0001887002,0.000006751146,0.001683303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01313888,"threshold_uncertainty_score":0.2163778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105180941588661,"score_gpt":0.3279510251465461,"score_spread":0.3174329309876799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}