{"id":"W2802667264","doi":"10.1016/j.cell.2018.03.056","title":"FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":944,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Research Council; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; ALS Society of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Medical Research Council; Royal Society; Wellcome Trust; Fondation Brain Canada","keywords":"Biology; Methylation; Arginine; Chaperone (clinical); DNA methylation; Cell biology; Computational biology; Genetics; Biophysics; DNA; Amino acid; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009847777,0.0001478097,0.0001227117,0.00007546494,0.0001497336,0.0001715637,0.000106997,0.0001290987,0.0005099273],"category_scores_gemma":[0.0001187507,0.00007636688,0.0001064876,0.00006351371,0.0002071085,0.0001679947,0.0001870995,0.0001752472,0.0001321347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002277272,"about_ca_system_score_gemma":0.0001207249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003820224,"about_ca_topic_score_gemma":0.0005919495,"domain_scores_codex":[0.9999402,0.000008108018,0.000004608193,0.00001445292,0.00001763197,0.00001500244],"domain_scores_gemma":[0.9999286,0.000009731589,0.00003245308,0.000005295647,0.000009347199,0.00001465039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003053013,0.000003024261,0.0001263251,0.000005792227,9.435112e-7,0.00001905553,0.000005810451,0.000029345,0.9993285,0.00005930861,0.000008742324,0.0003826516],"study_design_scores_gemma":[0.000005608072,0.00005180329,0.004021311,0.00000176547,0.00000403991,0.0001269703,0.00001553462,0.001070378,0.9939752,0.00008343649,0.0006408451,0.000003118357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997367,0.0002849233,0.00170349,0.00004065579,0.000005777821,0.000003767028,0.0000214816,0.00003840533,0.0005345432],"genre_scores_gemma":[0.9990222,0.0001163482,0.0004903941,0.00001269504,0.000002643677,0.00000293712,0.00002932121,0.000005628952,0.0003178687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005099273,"threshold_uncertainty_score":0.001705825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105180941588661,"score_gpt":0.3279510251465461,"score_spread":0.3174329309876799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}