{"id":"W2802671986","doi":"10.1038/aps.2018.31","title":"TRPM2: a candidate therapeutic target for treating neurological diseases","year":2018,"lang":"en","type":"review","venue":"Acta Pharmacologica Sinica","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Manitoba; Western University","funders":"Canadian Institutes of Health Research","keywords":"TRPM2; Transient receptor potential channel; Neuroscience; Glutamate receptor; Amyotrophic lateral sclerosis; Disease; Medicine; Excitotoxicity; Stroke (engine); NMDA receptor; Biology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002870106,0.0005656034,0.0007805549,0.001602303,0.0002202768,0.0005632084,0.000527349,0.0009924978,0.004366953],"category_scores_gemma":[0.0002764147,0.0001456715,0.000490837,0.0009695548,0.0003128761,0.0007447355,0.0004101348,0.00161556,0.001819734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003207221,"about_ca_system_score_gemma":0.0005276129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004151505,"about_ca_topic_score_gemma":0.0007591477,"domain_scores_codex":[0.9999142,0.00001450881,0.00001146489,0.00001846472,0.00002950873,0.0000118691],"domain_scores_gemma":[0.9999028,0.00003144863,0.00001618747,0.000003646514,0.00003271678,0.00001322789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001289077,0.0001799583,0.0002045823,0.0126564,0.00009066596,0.0003765855,0.0000530092,0.0004341342,0.008127783,0.004763152,0.03002443,0.9429604],"study_design_scores_gemma":[0.00004612446,0.0002630042,0.001073388,0.002105399,0.0001601533,0.002377635,0.00006792424,0.0002864011,0.002120043,0.002750253,0.9887239,0.00002591009],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004856508,0.9964001,0.0003628596,0.0005460694,0.0003530059,0.00001149994,0.00003721485,0.00002010026,0.001783367],"genre_scores_gemma":[0.003073088,0.9945363,0.0004286506,0.0003612288,0.0002622559,0.00001618726,0.00005738246,0.000002841159,0.001261976],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004366953,"threshold_uncertainty_score":0.01460898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1396601979454702,"score_gpt":0.4154692807281357,"score_spread":0.2758090827826655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}