{"id":"W2802671986","doi":"10.1038/aps.2018.31","title":"TRPM2: a candidate therapeutic target for treating neurological diseases","year":2018,"lang":"en","type":"review","venue":"Acta Pharmacologica Sinica","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Manitoba; Western University","funders":"Canadian Institutes of Health Research","keywords":"TRPM2; Transient receptor potential channel; Neuroscience; Glutamate receptor; Amyotrophic lateral sclerosis; Disease; Medicine; Excitotoxicity; Stroke (engine); NMDA receptor; Biology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003324006,0.000834202,0.001956939,0.0001638665,0.0006638592,0.0001442245,0.001321351,0.0005356149,0.001643336],"category_scores_gemma":[0.0009766968,0.0004946301,0.001238719,0.0004893369,0.0004972449,0.0001322587,0.0003356019,0.0006288993,0.0001822572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006751549,"about_ca_system_score_gemma":0.000282924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001497756,"about_ca_topic_score_gemma":2.202496e-7,"domain_scores_codex":[0.995133,0.001073505,0.0009424161,0.001549518,0.0003188646,0.0009827393],"domain_scores_gemma":[0.9950328,0.003389193,0.0008200679,0.0003464709,0.00006054561,0.0003508504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004541603,0.001464821,0.000003122719,0.004692085,0.0002826495,0.00020195,0.00007436054,0.000003246409,0.001738723,0.0001775463,0.07934206,0.9115652],"study_design_scores_gemma":[0.0005897324,0.001149476,6.310357e-7,0.0003599645,0.001008024,0.00005662304,0.0000026452,0.0002309201,0.0005317907,0.0001580423,0.9953005,0.0006116021],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003566236,0.9903567,0.00002378614,0.0004595522,0.003276755,0.003196665,0.001012374,0.0004513997,0.0008660717],"genre_scores_gemma":[0.006441267,0.9869543,0.0001442561,0.002310874,0.001865966,0.001158167,0.0001033816,0.0001080467,0.0009137908],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9159585,"threshold_uncertainty_score":0.9997506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1396601979454702,"score_gpt":0.4154692807281357,"score_spread":0.2758090827826655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}