{"id":"W2802677271","doi":"","title":"Design, Synthesis and Evaluation of Substituted Aryl-2-Nitrovinyl Derivatives as Small Molecules Proteasome Inhibitors.","year":2018,"lang":"en","type":"article","venue":"PubMed","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Winnipeg","funders":"","keywords":"Steric effects; Aryl; Chemistry; Bortezomib; Proteasome; Acceptor; Cytotoxicity; Stereochemistry; Molecule; Docking (animal); Proteasome inhibitor; Enzyme; IC50; Ring (chemistry); Small molecule; In vitro; Biochemistry; Organic chemistry; Alkyl; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866652,0.0004855134,0.0003995842,0.0002955415,0.0001923943,0.0002586515,0.0004091745,0.0002649177,0.001390916],"category_scores_gemma":[0.0001373326,0.000198672,0.0002511731,0.0003083525,0.0001497913,0.0002902267,0.0001798581,0.0003628885,0.0004581318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958183,"about_ca_system_score_gemma":0.0003640254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007719531,"about_ca_topic_score_gemma":0.002486051,"domain_scores_codex":[0.9999167,0.00001276436,0.000008502897,0.00001648245,0.00002114715,0.00002457107],"domain_scores_gemma":[0.9999468,0.000003328114,0.00001752595,0.000004324322,0.00001118503,0.00001679703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004140775,0.0003757413,0.0003260017,0.0005402077,0.00005418164,0.0005837708,0.00007610684,0.002331027,0.9628638,0.001892836,0.0008605382,0.02968172],"study_design_scores_gemma":[0.0004597945,0.007031917,0.002254359,0.00005767882,0.0001862028,0.0009699257,0.00004604327,0.002420604,0.9453235,0.0003180463,0.04087877,0.00005325508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9160846,0.03292828,0.02971808,0.0005496213,0.0002960453,0.001531537,0.002332321,0.0004083656,0.01615105],"genre_scores_gemma":[0.9596201,0.01496179,0.01746878,0.0001831499,0.00005160942,0.0003729391,0.001323342,0.00003336463,0.005984917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390916,"threshold_uncertainty_score":0.004653037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04567126429133864,"score_gpt":0.2503477818220503,"score_spread":0.2046765175307116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}