{"id":"W2802710454","doi":"10.1016/j.omtm.2018.04.007","title":"An Integrated Approach toward the Biomanufacturing of Engineered Cell Therapy Products in a Stirred-Suspension Bioreactor","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Biomanufacturing; Bioreactor; Microcarrier; Cell therapy; Cell culture; Process development; Bioprocess; Biochemical engineering; Stem cell; Biotechnology; Biology; Process engineering; Cell biology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001009003,0.001098496,0.0008094782,0.0008358124,0.0004486245,0.001087308,0.001116671,0.001076582,0.0004869156],"category_scores_gemma":[0.0003905478,0.0006111568,0.001008886,0.0004449195,0.0005078834,0.0006715002,0.001009897,0.001503208,0.000666392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009260085,"about_ca_system_score_gemma":0.001369633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001106971,"about_ca_topic_score_gemma":0.001923542,"domain_scores_codex":[0.9985241,0.0001490404,0.0001439824,0.0003566188,0.000726469,0.00009974047],"domain_scores_gemma":[0.9997023,0.00006048679,0.00008768589,0.00004548854,0.00006257396,0.00004149287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003415177,0.00008434992,0.00007987575,0.00005826223,0.00001048189,0.00003049747,0.00002708414,0.0004398155,0.9934663,0.0003387094,0.00007429826,0.005356072],"study_design_scores_gemma":[0.00001783122,0.0002826717,0.0003084591,0.000004920272,0.00002781095,0.000122262,0.000007852537,0.00460447,0.9916459,0.0000650156,0.002887681,0.00002523431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.23672,0.004096942,0.7519004,0.0004508829,0.0003484349,0.000811248,0.0004026477,0.002604154,0.002665424],"genre_scores_gemma":[0.3245254,0.002598765,0.6683828,0.0002012569,0.00008964187,0.0006379072,0.0006852102,0.0001059544,0.002773051],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001116671,"threshold_uncertainty_score":0.006718636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1573811165511435,"score_gpt":0.4454988719340875,"score_spread":0.288117755382944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}