{"id":"W2802748326","doi":"10.1097/hs9.0000000000000044","title":"Clinical Utility of Next‐generation Sequencing in the Management of Myeloproliferative Neoplasms: A Single‐Center Experience","year":2018,"lang":"en","type":"article","venue":"HemaSphere","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"European Hematology Association; Bristol-Myers Squibb","keywords":"Medicine; Myeloid; Oncology; Internal medicine; Myelofibrosis; DNA sequencing; Bioinformatics; Gene; Biology; Genetics; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002911179,0.0003556362,0.0004312252,0.0002272469,0.0004094114,0.0007705442,0.0002568124,0.0004941989,0.002525423],"category_scores_gemma":[0.002887746,0.0001356897,0.0004081581,0.0002473798,0.0002794951,0.0005251767,0.0004132245,0.0007985465,0.001013631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754813,"about_ca_system_score_gemma":0.0005071147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004614642,"about_ca_topic_score_gemma":0.001091589,"domain_scores_codex":[0.9992886,0.0003561787,0.00005104128,0.0001422607,0.00009449692,0.00006747783],"domain_scores_gemma":[0.9986284,0.0006546588,0.000130733,0.0001351332,0.0001959283,0.0002551704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002655913,0.00189351,0.1609644,0.0004907392,0.0006103525,0.0053238,0.001265477,0.00391257,0.04866377,0.0007730494,0.01344922,0.7599972],"study_design_scores_gemma":[0.002067418,0.03394613,0.5075617,0.001498597,0.002320409,0.08848887,0.002622027,0.03886754,0.1108596,0.005906213,0.2055509,0.0003105677],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9226653,0.01600864,0.04292406,0.003000902,0.0004774385,0.0006721913,0.001230704,0.0004561636,0.01256466],"genre_scores_gemma":[0.9744343,0.004184844,0.01589482,0.002255556,0.0002128078,0.0001666165,0.001127068,0.0001465738,0.001577394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002911179,"threshold_uncertainty_score":0.015396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1708202741207578,"score_gpt":0.3693284758710335,"score_spread":0.1985082017502757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}