{"id":"W2802748326","doi":"10.1097/hs9.0000000000000044","title":"Clinical Utility of Next‐generation Sequencing in the Management of Myeloproliferative Neoplasms: A Single‐Center Experience","year":2018,"lang":"en","type":"article","venue":"HemaSphere","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"European Hematology Association; Bristol-Myers Squibb","keywords":"Medicine; Myeloid; Oncology; Internal medicine; Myelofibrosis; DNA sequencing; Bioinformatics; Gene; Biology; Genetics; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004500155,0.0001842724,0.0004453806,0.00003523217,0.00006347735,0.00001561151,0.0001210196,0.00009227573,0.0004983235],"category_scores_gemma":[0.00006064619,0.000119142,0.0001281631,0.0002817402,0.0003022961,0.0001145711,0.00005434318,0.0001370921,0.00001451772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009266441,"about_ca_system_score_gemma":0.0001000184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006277396,"about_ca_topic_score_gemma":0.000291673,"domain_scores_codex":[0.998073,0.0001853024,0.0007632547,0.0003716652,0.0003886321,0.000218129],"domain_scores_gemma":[0.9989189,0.0001235872,0.0002144196,0.0004565247,0.0002219721,0.00006460037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008228398,0.00334494,0.9203704,0.0005350121,0.0005015865,0.000175076,0.02485688,0.000007659661,0.006947116,0.006017476,0.001470758,0.03495025],"study_design_scores_gemma":[0.01391379,0.007632261,0.5448128,0.003388029,0.0005682504,0.0002552792,0.04576325,0.01311623,0.364021,0.0006660181,0.005114896,0.0007481998],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878242,0.0002688657,0.0002890946,0.0003054495,0.0001445694,0.0008386332,0.000007928315,0.00001243098,0.01030881],"genre_scores_gemma":[0.9929632,0.0001710355,0.006033311,0.0004037922,0.0001634138,0.0001339718,0.00001719484,0.0000119316,0.0001021488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3755576,"threshold_uncertainty_score":0.5456293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1708202741207578,"score_gpt":0.3693284758710335,"score_spread":0.1985082017502757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}