{"id":"W2802750631","doi":"10.1016/j.stemcr.2018.04.003","title":"CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo Transplantation Failure","year":2018,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Biology; CXCR4; Induced pluripotent stem cell; Progenitor cell; Haematopoiesis; Transplantation; Stem cell; Cell biology; Ectopic expression; Cancer research; Somatic cell; Hematopoietic stem cell; Immunology; Bone marrow; Embryonic stem cell; Cell culture; Genetics; Chemokine; Internal medicine; Medicine; Inflammation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002713822,0.0002538239,0.00022731,0.0002322923,0.0001059346,0.0002694342,0.0001496475,0.0001844899,0.00132356],"category_scores_gemma":[0.0001077174,0.00008059457,0.0001511128,0.0001200591,0.00014721,0.0001316288,0.000202124,0.0005251832,0.0002804248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001812402,"about_ca_system_score_gemma":0.0003138914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006215074,"about_ca_topic_score_gemma":0.0009880249,"domain_scores_codex":[0.9998136,0.0000447215,0.00002098215,0.00002034918,0.0000474163,0.00005287442],"domain_scores_gemma":[0.9999233,0.00001581535,0.00001510293,0.00001115622,0.000007987383,0.00002650581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008451042,0.0000789315,0.0002798007,0.00003169292,0.000004074187,0.00003700557,0.00001280945,0.0001086579,0.9965135,0.0000886177,0.00007283044,0.00268771],"study_design_scores_gemma":[0.00001132276,0.0004035579,0.002499775,0.00000365883,0.00001025296,0.0001348841,0.00001438213,0.0007340236,0.9948679,0.00001676954,0.001301952,0.000001554871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959762,0.0004752854,0.001839826,0.00006771308,0.00001329279,0.00003759188,0.000201498,0.0001237037,0.001264902],"genre_scores_gemma":[0.9948404,0.0004143454,0.00205517,0.00003800881,0.000006399615,0.00002982833,0.0004181924,0.00002277795,0.002174804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00132356,"threshold_uncertainty_score":0.004427731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256854684355858,"score_gpt":0.2492173287699778,"score_spread":0.2366487819264192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}