{"id":"W2802750631","doi":"10.1016/j.stemcr.2018.04.003","title":"CXCL12/CXCR4 Signaling Enhances Human PSC-Derived Hematopoietic Progenitor Function and Overcomes Early In Vivo Transplantation Failure","year":2018,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Biology; CXCR4; Induced pluripotent stem cell; Progenitor cell; Haematopoiesis; Transplantation; Stem cell; Cell biology; Ectopic expression; Cancer research; Somatic cell; Hematopoietic stem cell; Immunology; Bone marrow; Embryonic stem cell; Cell culture; Genetics; Chemokine; Internal medicine; Medicine; Inflammation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004261415,0.0002968845,0.0004639096,0.0002362962,0.0001686237,0.00006170454,0.0000487447,0.0002122902,0.0002239305],"category_scores_gemma":[0.000006163832,0.0002797198,0.00009012645,0.0002766151,0.0001303457,0.0002435011,0.00001094675,0.0001899107,0.00001898322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006825336,"about_ca_system_score_gemma":0.00009672453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001053314,"about_ca_topic_score_gemma":0.0001423863,"domain_scores_codex":[0.9975453,0.00008634973,0.0008556123,0.0006233716,0.0005170396,0.0003723295],"domain_scores_gemma":[0.9989736,0.00007910559,0.0003169502,0.0003214832,0.0001364964,0.0001723759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001764257,0.0001110568,0.07782606,0.001420756,0.00003825998,0.0007348591,0.00467346,0.000001938203,0.9146987,0.00004420818,0.00004055729,0.0002337802],"study_design_scores_gemma":[0.001452266,0.0005882775,0.04122445,0.0008374318,0.0002816193,0.0013368,0.001213223,0.00002272845,0.9522228,0.0003158324,0.0001833779,0.0003212524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941089,0.0002233835,0.001208943,0.00006917557,0.0003570296,0.001040038,0.000004841271,0.0001308312,0.002856846],"genre_scores_gemma":[0.9982759,0.00004375146,0.0006404903,0.00004953437,0.0002180075,0.00008227622,0.00003491083,0.00005027999,0.0006049021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03752411,"threshold_uncertainty_score":0.9999655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256854684355858,"score_gpt":0.2492173287699778,"score_spread":0.2366487819264192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}