{"id":"W2802759755","doi":"10.1016/j.chom.2018.04.008","title":"Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria","year":2018,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Toronto","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Vertex Pharmaceuticals","keywords":"Biology; Autophagy; Intracellular parasite; Microbiology; Shigella flexneri; Intracellular; Bacteria; Lytic cycle; Listeria monocytogenes; Alternative complement pathway; Proteases; Complement system; Salmonella enterica; Shigella; Bacterial outer membrane; Immune system; Cell biology; Salmonella; Virology; Apoptosis; Immunology; Enzyme; Biochemistry; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003078355,0.0004532416,0.0003695836,0.0004764166,0.0003950608,0.0006692589,0.0004109163,0.0005679763,0.002269766],"category_scores_gemma":[0.0002276316,0.0002207557,0.0004960395,0.000296273,0.0006499868,0.0002604438,0.0004962192,0.0009614454,0.0007065099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00147974,"about_ca_system_score_gemma":0.001073563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00419786,"about_ca_topic_score_gemma":0.007041719,"domain_scores_codex":[0.9994621,0.00007132873,0.00004003706,0.00007271794,0.000119783,0.0002340803],"domain_scores_gemma":[0.9996277,0.00008016201,0.00008809298,0.00006634113,0.00004606839,0.00009153532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003115505,0.0000495612,0.00006193602,0.00002459755,0.000003333052,0.00003466644,0.00001418933,0.00005935882,0.9983895,0.0003518725,0.00007760195,0.0006218034],"study_design_scores_gemma":[0.00002091028,0.0001151513,0.001007818,0.000005103549,0.000005857925,0.00007504568,0.00002739506,0.0007731584,0.9969512,0.00006941459,0.0009441346,0.000004756345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922304,0.0008650664,0.00186085,0.0002529287,0.00005889925,0.00005125862,0.0007085481,0.0001490346,0.00382316],"genre_scores_gemma":[0.9952129,0.0002481504,0.001207555,0.00006184315,0.000007550157,0.00003025315,0.0003336444,0.00004396429,0.002854102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00419786,"threshold_uncertainty_score":0.01073635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339625932205541,"score_gpt":0.2703545536111312,"score_spread":0.2569582942890758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}