{"id":"W2802759755","doi":"10.1016/j.chom.2018.04.008","title":"Complement C3 Drives Autophagy-Dependent Restriction of Cyto-invasive Bacteria","year":2018,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Toronto","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; Vertex Pharmaceuticals","keywords":"Biology; Autophagy; Intracellular parasite; Microbiology; Shigella flexneri; Intracellular; Bacteria; Lytic cycle; Listeria monocytogenes; Alternative complement pathway; Proteases; Complement system; Salmonella enterica; Shigella; Bacterial outer membrane; Immune system; Cell biology; Salmonella; Virology; Apoptosis; Immunology; Enzyme; Biochemistry; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009830156,0.0001943739,0.0003155711,0.0001177572,0.0001037963,0.00001542949,0.0001418857,0.00009240775,0.002170513],"category_scores_gemma":[0.0000149812,0.0001757603,0.0001345197,0.0001495129,0.0001748804,0.0000655217,0.00007689963,0.0001122837,0.0003340425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009189867,"about_ca_system_score_gemma":0.0001697368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007379815,"about_ca_topic_score_gemma":0.00001327464,"domain_scores_codex":[0.9987852,0.00004928068,0.000368055,0.0003122283,0.0001994406,0.0002858116],"domain_scores_gemma":[0.998979,0.0000406106,0.0001936637,0.0004504143,0.0001871211,0.0001491583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002407589,0.0004105534,0.001979364,0.0001008825,0.00009151992,0.00003844612,0.0006390008,2.901663e-7,0.9914829,0.0001269809,0.004394901,0.0004944348],"study_design_scores_gemma":[0.001988688,0.0007336268,0.06716213,0.0001045366,0.0001219605,0.00001635281,0.0002429884,0.000007437176,0.9162446,0.00008794017,0.01314653,0.0001432497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934032,0.0006742744,0.0002527263,0.0001362383,0.000514466,0.0004602524,0.00007302435,0.00007101454,0.004414835],"genre_scores_gemma":[0.99568,0.0004785811,0.0008781134,0.0004966949,0.0004223323,0.00001397326,0.0001098525,0.00003254628,0.001887946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0752383,"threshold_uncertainty_score":0.9987416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339625932205541,"score_gpt":0.2703545536111312,"score_spread":0.2569582942890758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}