{"id":"W2802773414","doi":"10.1371/journal.pone.0196117","title":"Identification of a neutrophil-related gene expression signature that is enriched in adult systemic lupus erythematosus patients with active nephritis: Clinical/pathologic associations and etiologic mechanisms","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; University Health Network; University of Toronto; Toronto General Hospital; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Government of Ontario; University of Toronto; University Health Network; Arthritis Society; Ontario Institute for Cancer Research; Eli Lilly and Company","keywords":"Lupus nephritis; Medicine; Absolute neutrophil count; Transcriptome; Cohort; Biomarker; Internal medicine; Immunology; Gene signature; Gene expression profiling; Nephritis; Gene expression; Disease; Biology; Neutropenia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007922957,0.0002453013,0.0008957958,0.0003095127,0.00009993213,0.00002162209,0.0001858848,0.0005631526,0.00003377458],"category_scores_gemma":[0.001019655,0.0001822234,0.00007924947,0.0005271417,0.0002211495,0.0001567633,0.0001119042,0.0005155284,0.00002851023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942806,"about_ca_system_score_gemma":0.0000866788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001170408,"about_ca_topic_score_gemma":0.0000054498,"domain_scores_codex":[0.9966484,0.0005181899,0.0009753213,0.0006300223,0.0008665954,0.0003614794],"domain_scores_gemma":[0.996933,0.0003602011,0.0008455353,0.0005511519,0.001166681,0.0001434333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005662552,0.001806241,0.5415312,0.0005205256,0.0003021883,0.00002533942,0.002319935,3.907653e-7,0.4526626,0.00008832767,0.00004116421,0.0001358495],"study_design_scores_gemma":[0.02790873,0.005112264,0.4982272,0.01244366,0.001333538,0.001728613,0.005183588,0.001038384,0.4421836,0.003964665,0.000001042821,0.0008747429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965018,0.0005194768,0.0001704727,0.0001984368,0.0001060987,0.002248514,0.00009971908,0.00008867863,0.000066814],"genre_scores_gemma":[0.9974905,0.0004821353,0.001348263,0.0001001629,0.00005529245,0.0001987409,0.0001071959,0.00004379251,0.0001739352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04330404,"threshold_uncertainty_score":0.7430857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03560532737616165,"score_gpt":0.2825659574431855,"score_spread":0.2469606300670238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}