{"id":"W2802777894","doi":"10.1016/j.stemcr.2018.03.025","title":"INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice","year":2018,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Foundation for Innovation; Cole Foundation; Warren H. and Clara Cole Foundation","keywords":"Neurogenesis; Biology; Doublecortin; Subventricular zone; Bromodeoxyuridine; Microglia; Cell biology; Neural stem cell; Hippocampus; Molecular biology; Cancer research; Dentate gyrus; Stem cell; Neuroscience; Immunology; Immunohistochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002679535,0.0009242028,0.0005269711,0.001516956,0.0002642983,0.0003654214,0.0005487151,0.0006723201,0.002280806],"category_scores_gemma":[0.0001697549,0.0004627716,0.0004982523,0.0003255745,0.0006437277,0.0004240545,0.0003224614,0.001293514,0.0006717098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002721561,"about_ca_system_score_gemma":0.000252092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004084064,"about_ca_topic_score_gemma":0.0004621126,"domain_scores_codex":[0.9997635,0.00003149647,0.00003784857,0.00006472995,0.00005324144,0.00004906969],"domain_scores_gemma":[0.9996687,0.00004653202,0.0001430503,0.00003573666,0.00001629849,0.00008965757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003216261,0.000071971,0.0001850854,0.00004048655,0.00001294436,0.0001077952,0.00004012794,0.00006518037,0.9978083,0.0001498425,0.00003166484,0.00116493],"study_design_scores_gemma":[0.00003875637,0.0006480447,0.003028695,0.00001872135,0.0000411376,0.0003513193,0.00005082073,0.0005133594,0.9937246,0.0001833018,0.001392959,0.000008326489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940236,0.001196239,0.002419897,0.0001197663,0.0000471566,0.0000334464,0.0005922961,0.0002491559,0.001318381],"genre_scores_gemma":[0.9808151,0.002423489,0.005446738,0.0001090773,0.0000276455,0.0001741303,0.001112256,0.0001934817,0.009698259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002280806,"threshold_uncertainty_score":0.00763005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649159636617385,"score_gpt":0.2472588175342433,"score_spread":0.2207672211680695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}