{"id":"W2802788852","doi":"10.3389/fcell.2018.00046","title":"Translation of CRISPR Genome Surgery to the Bedside for Retinal Diseases","year":2018,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; New York State Department of Health - Wadsworth Center; Crowley Family Foundation; Research to Prevent Blindness; National Cancer Institute; National Institutes of Health; Foundation Fighting Blindness","keywords":"CRISPR; Genome editing; Genome; Biology; Bioinformatics; Medicine; Computational biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005385045,0.0007397287,0.0007238756,0.001711517,0.0002477227,0.001003511,0.0005927425,0.0009943291,0.006968371],"category_scores_gemma":[0.0006921049,0.0002565887,0.0005323361,0.0008856484,0.0004071945,0.00121762,0.0007586744,0.001708315,0.004091538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005940376,"about_ca_system_score_gemma":0.00118107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005645671,"about_ca_topic_score_gemma":0.001049951,"domain_scores_codex":[0.9997961,0.00002859577,0.00003194117,0.00003496478,0.00008678932,0.00002167438],"domain_scores_gemma":[0.9997472,0.0001110002,0.0000347782,0.00001087011,0.00007105953,0.00002510972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004886825,0.0000383703,0.000102001,0.01242297,0.00005988709,0.0002839803,0.00007118104,0.0003208777,0.006692547,0.009207753,0.03484251,0.935909],"study_design_scores_gemma":[0.000006113849,0.00004230054,0.0002245302,0.00139545,0.00003831183,0.0007661431,0.00002404543,0.00005571703,0.001903258,0.001696758,0.993835,0.00001245597],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002796781,0.9913397,0.001358712,0.0007400673,0.0008094856,0.00001671946,0.00006596764,0.00007234558,0.005317228],"genre_scores_gemma":[0.001479561,0.9938024,0.001098102,0.0004752904,0.0002125401,0.00001634461,0.0001001843,0.0000122591,0.002803266],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006968371,"threshold_uncertainty_score":0.02331156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967030164600226,"score_gpt":0.3141569921370419,"score_spread":0.2944866904910396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}