{"id":"W2802835889","doi":"10.1002/ejoc.201800163","title":"Deazapurine Analogues Bearing a 1<i>H</i>‐Pyrazolo[3,4‐<i>b</i>]pyridin‐3(2<i>H</i>)‐one Core: Synthesis and Biological Activity","year":2018,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Regioselectivity; Stereochemistry; Alkaline phosphatase; Phosphodiesterase; Enzyme; Nucleotide; Docking (animal); Biological activity; Biochemistry; Catalysis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008104476,0.0002323248,0.0002924453,0.00003275322,0.0001230972,0.00004926567,0.0004588283,0.0001198806,0.0002232223],"category_scores_gemma":[0.0007424527,0.0001959453,0.0001421054,0.0001464504,0.0004854313,0.000008188455,0.0005086088,0.0003576993,0.00001895531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002192527,"about_ca_system_score_gemma":0.00008344204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001501418,"about_ca_topic_score_gemma":9.381276e-7,"domain_scores_codex":[0.998523,0.0001367322,0.0003546097,0.0003831276,0.00024912,0.0003534323],"domain_scores_gemma":[0.9988372,0.00003561416,0.000233957,0.0003371385,0.0002494722,0.000306557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002704403,0.0001232716,0.001056808,0.00003415006,0.0001284913,0.00008158761,0.00002258694,1.123503e-7,0.9917467,0.00000148763,0.0007507904,0.005783634],"study_design_scores_gemma":[0.0005732209,0.0004247122,0.004797728,0.00005901442,0.00003798699,0.0006167323,0.00002779156,0.00000308884,0.9835122,0.00001751409,0.009698804,0.0002312076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954393,0.0009256067,0.0007579075,0.0003007517,0.00005572227,0.00005477471,0.000008914433,0.0000133809,0.002443671],"genre_scores_gemma":[0.9968973,0.0007560779,0.0008513315,0.0001614358,0.001069772,0.000001075277,0.000009586364,0.00004432132,0.0002090628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008948014,"threshold_uncertainty_score":0.7990417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03045908182894776,"score_gpt":0.2508669729441776,"score_spread":0.2204078911152298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}