{"id":"W2802900288","doi":"10.1016/j.jcyt.2018.02.304","title":"A new immunotherapy approach against acute lymphoblastic leukemia by transducing hematopoietic stem cells with a car under regulation of cell specific promoter","year":2018,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Chimeric antigen receptor; Haematopoiesis; Cytotoxic T cell; Cancer research; Stem cell; Transgene; Biology; Immunotherapy; Leukemia; Hematopoietic stem cell; Genetic enhancement; Immunology; Cell biology; In vitro; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134886,0.000434638,0.0003121738,0.0004718479,0.0001948302,0.0004601192,0.0003126572,0.0003975639,0.000964839],"category_scores_gemma":[0.00008146928,0.0001543781,0.0003444679,0.0002627273,0.000359373,0.00035613,0.0002909218,0.000954789,0.000261895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002925944,"about_ca_system_score_gemma":0.0003922293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003044014,"about_ca_topic_score_gemma":0.0003152259,"domain_scores_codex":[0.9998806,0.00001937942,0.000006249157,0.00003452253,0.00003203041,0.00002729754],"domain_scores_gemma":[0.9999636,0.000009415963,0.000007695895,0.000006568783,0.000005851938,0.000006822004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001125276,0.000165008,0.0004429518,0.0001272612,0.00001837604,0.0001713897,0.00007573504,0.0004740542,0.9725594,0.004997147,0.000375848,0.02048028],"study_design_scores_gemma":[0.0001112203,0.0008351745,0.00103889,0.00001356055,0.000122417,0.001033241,0.00003402654,0.002938976,0.9689794,0.0008156251,0.02406376,0.00001366682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8359478,0.01443373,0.1341179,0.001339205,0.0004395442,0.0003969446,0.000350864,0.00122211,0.01175187],"genre_scores_gemma":[0.9656252,0.003935972,0.02367347,0.0002617946,0.00007373897,0.0001851924,0.0002694274,0.0000495196,0.005925734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000964839,"threshold_uncertainty_score":0.00322777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171394913583134,"score_gpt":0.2489090784470509,"score_spread":0.2317695870887375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}