{"id":"W2803026631","doi":"10.3747/co.25.4044","title":"Evidence-Based Best Practices for EGFR T790M Testing in Lung Cancer in Canada","year":2018,"lang":"en","type":"article","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Canada's Michael Smith Genome Sciences Centre; McGill University Health Centre; BC Cancer Foundation; University Health Network; Toronto General Hospital; University of Toronto; William Osler Health System; Princess Margaret Cancer Centre; BC Cancer Agency; Ottawa Hospital","funders":"Universitair Medisch Centrum Groningen; Université de Montréal; University of Alberta; AstraZeneca Canada; McGill University Health Centre; McGill University; Alberta Health Services; AstraZeneca","keywords":"Medicine; Osimertinib; T790M; Lung cancer; Oncology; Epidermal growth factor receptor; Internal medicine; Genetic testing; Cancer; Personalized medicine; Intensive care medicine; Bioinformatics; Erlotinib; Gefitinib","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04032755,0.0008502667,0.001936026,0.01114578,0.004153123,0.00682182,0.008628783,0.003684247,0.005124463],"category_scores_gemma":[0.1583136,0.00108112,0.003376428,0.01348315,0.002320392,0.002209472,0.003887699,0.004716632,0.00073857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.1022636,"about_ca_system_score_gemma":0.3226359,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9388643,"about_ca_topic_score_gemma":0.9678394,"domain_scores_codex":[0.9442445,0.0157131,0.01323754,0.001580342,0.02295536,0.00226916],"domain_scores_gemma":[0.7957483,0.0347066,0.0167247,0.003112018,0.1392331,0.01047533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004132994,0.0002970609,0.02950779,0.04867069,0.001645255,0.0007536592,0.002466105,0.003928889,0.0005076315,0.01067803,0.3287892,0.5723423],"study_design_scores_gemma":[0.001061648,0.0003087071,0.09638551,0.3783953,0.003781116,0.0006487959,0.003236906,0.003566653,0.00116122,0.008057957,0.5029893,0.000406808],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01515841,0.515811,0.01002441,0.3422707,0.006573357,0.004965485,0.01230528,0.0004853754,0.09240612],"genre_scores_gemma":[0.2889201,0.4705994,0.1468375,0.07122205,0.001269148,0.003926234,0.01089386,0.000267059,0.006064542],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1022636,"threshold_uncertainty_score":0.7419782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3124568494135863,"score_gpt":0.5412194137319866,"score_spread":0.2287625643184003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}