{"id":"W2803033440","doi":"10.1038/s41419-018-0534-9","title":"HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway","year":2018,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Key Research and Development Program of China; Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Fonds de Recherche du Québec - Santé; Tianjin Medical University; National Natural Science Foundation of China","keywords":"Microvesicles; Exosome; Cancer research; Metastasis; Epithelial–mesenchymal transition; Biology; Gene knockdown; MAPK/ERK pathway; Cell migration; Cell; Cell biology; Cancer; Cell culture; microRNA; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025525,0.0002498561,0.0001627988,0.00002416646,0.0002322042,0.00006763045,0.0001268917,0.0001279893,0.00003433235],"category_scores_gemma":[0.00006849807,0.0002302689,0.0000749102,0.00005853124,0.0002632687,0.00002184863,0.00008512448,0.00008333062,0.0000115311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007892084,"about_ca_system_score_gemma":0.0001047703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005558448,"about_ca_topic_score_gemma":0.000001191102,"domain_scores_codex":[0.9985942,0.00009047501,0.0002067975,0.0006080936,0.0001675232,0.0003329638],"domain_scores_gemma":[0.9990076,0.00001575817,0.0000810069,0.0002474841,0.00007835566,0.0005697453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004882003,0.0002252933,0.001164434,0.0001537639,0.00001442484,0.00003140491,0.0002025416,0.000002289961,0.9906332,0.00005841949,0.0007392965,0.006286744],"study_design_scores_gemma":[0.001568018,0.0005148909,0.001989205,0.0001444584,0.0001096846,0.000007332792,0.0001277955,0.0006607582,0.9845701,0.001965022,0.007776217,0.0005665192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733518,0.01986109,0.005466205,0.000132766,0.00008292789,0.0003313288,0.0002305081,0.00003056256,0.0005127882],"genre_scores_gemma":[0.9961273,0.001360943,0.001196791,0.0004159274,0.0003123569,0.00003892322,0.0003386273,0.00002973402,0.0001793676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0227755,"threshold_uncertainty_score":0.9390094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009349392731031528,"score_gpt":0.2470203419297727,"score_spread":0.2376709491987412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}