{"id":"W2803038080","doi":"10.1074/jbc.m117.812016","title":"Dual functionality of β-tryptase protomers as both proteases and cofactors in the active tetramer","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"","keywords":"Tetramer; Allosteric regulation; Chemistry; Active site; Tryptase; Biochemistry; Proteases; Dimer; Protease; Enzyme; Cofactor; Biology; Mast cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065221,0.000298986,0.0001509707,0.0001124888,0.0001264928,0.0003902172,0.0003888215,0.0002417548,0.0005634382],"category_scores_gemma":[0.0001231763,0.0001278851,0.0002292806,0.0001377515,0.0002870576,0.0002333209,0.0002636254,0.0005134736,0.0002952207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872739,"about_ca_system_score_gemma":0.0001645682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004741143,"about_ca_topic_score_gemma":0.0004313107,"domain_scores_codex":[0.9998431,0.00002093132,0.00001418996,0.00004028451,0.00005297692,0.00002857763],"domain_scores_gemma":[0.9998572,0.00001396981,0.00004424762,0.00001783263,0.00001386624,0.00005293454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006960411,0.00001785687,0.0001708062,0.000009990148,0.000003618413,0.0000446407,0.00001625548,0.00004667956,0.9989041,0.0001653068,0.00001542026,0.0005357504],"study_design_scores_gemma":[0.00001776773,0.0001228006,0.002366876,0.000003520141,0.00001360848,0.0002829489,0.00002352792,0.001079565,0.9949176,0.00005708412,0.001109228,0.000005399219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966879,0.0002513969,0.00244003,0.00003803848,0.000008709118,0.00001117852,0.00007101579,0.00003060921,0.000461131],"genre_scores_gemma":[0.9963192,0.0001281774,0.002289898,0.00003658624,0.000003546992,0.00001104085,0.0001847877,0.00001704897,0.001009611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005634382,"threshold_uncertainty_score":0.002084374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02131371246751777,"score_gpt":0.2575680809406913,"score_spread":0.2362543684731735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}