{"id":"W2803056999","doi":"10.1111/jcmm.13651","title":"The <scp>SHH</scp>/Gli axis regulates <scp>CD</scp>90‐mediated liver cancer stem cell function by activating the <scp>IL</scp>6/<scp>JAK</scp>2 pathway","year":2018,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation, Science and Economic Development Canada","funders":"","keywords":"Cancer stem cell; Liver cancer; Cancer research; Gene knockdown; GLI1; Stem cell; Sonic hedgehog; Cancer; Cancer cell; Biology; GLI3; Pancreatic cancer; Chemistry; CD44; Cell; Molecular biology; Hedgehog signaling pathway; Apoptosis; Cell biology; Signal transduction; Gene expression; Biochemistry; Gene; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007112743,0.0002302313,0.0001563186,0.0002639161,0.0001079712,0.0003756238,0.00008662338,0.0001120535,0.001421401],"category_scores_gemma":[0.00006860339,0.0001045743,0.0001730184,0.0001552323,0.000165795,0.0001276473,0.0001987237,0.0003706042,0.000485114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002509812,"about_ca_system_score_gemma":0.0002491726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007227557,"about_ca_topic_score_gemma":0.001417989,"domain_scores_codex":[0.9999027,0.00001154076,0.000006166842,0.00001569734,0.00003689242,0.000026878],"domain_scores_gemma":[0.9999533,0.000005485698,0.00001586864,0.000004102059,0.000006148508,0.0000151374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008056871,0.00000719588,0.0006262571,0.00002914882,0.000004652562,0.00003939452,0.000008492689,0.00007564184,0.9971232,0.00006984513,0.00007173738,0.001863847],"study_design_scores_gemma":[0.00002203491,0.0001362131,0.02480402,0.00000606692,0.00002427659,0.0003093348,0.00004410609,0.001810237,0.969112,0.00007848615,0.003648564,0.000004634913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904923,0.001631496,0.003509684,0.0001261468,0.00001720764,0.00004639214,0.001060433,0.0001710115,0.002945285],"genre_scores_gemma":[0.9952177,0.0006765207,0.001339475,0.00004057193,0.000007868521,0.00003560632,0.001011839,0.00002260631,0.00164784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001421401,"threshold_uncertainty_score":0.00475502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007615916104242205,"score_gpt":0.2096246413942286,"score_spread":0.2020087252899864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}