{"id":"W2803056999","doi":"10.1111/jcmm.13651","title":"The <scp>SHH</scp>/Gli axis regulates <scp>CD</scp>90‐mediated liver cancer stem cell function by activating the <scp>IL</scp>6/<scp>JAK</scp>2 pathway","year":2018,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation, Science and Economic Development Canada","funders":"","keywords":"Cancer stem cell; Liver cancer; Cancer research; Gene knockdown; GLI1; Stem cell; Sonic hedgehog; Cancer; Cancer cell; Biology; GLI3; Pancreatic cancer; Chemistry; CD44; Cell; Molecular biology; Hedgehog signaling pathway; Apoptosis; Cell biology; Signal transduction; Gene expression; Biochemistry; Gene; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.002758067,0.0008486421,0.001163111,0.0003816692,0.001486029,0.000141989,0.0009686671,0.0008072704,0.00005684702],"category_scores_gemma":[0.00214888,0.0005098919,0.0004894483,0.0006713233,0.001839926,0.0003501803,0.0002201808,0.001789642,0.00008108415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421301,"about_ca_system_score_gemma":0.0003766595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001966595,"about_ca_topic_score_gemma":0.00001590895,"domain_scores_codex":[0.9942804,0.001679332,0.00153166,0.0006467073,0.0005432959,0.001318592],"domain_scores_gemma":[0.9909777,0.005325686,0.001809204,0.0008513962,0.0008314931,0.0002045377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000868503,0.000183843,0.0002398353,0.00007328356,0.00128982,0.0001115306,0.005763616,0.00000838827,0.9381872,0.0000899735,0.04513194,0.008833658],"study_design_scores_gemma":[0.002659702,0.001637863,0.00123679,0.0002707583,0.0003331956,0.0002738841,0.006782842,0.00002900959,0.5382352,0.00009114113,0.4484034,0.0000461961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7496494,0.2436831,0.00224394,0.0003861964,0.002307065,0.0005137767,0.00003332591,0.00006125564,0.001121898],"genre_scores_gemma":[0.9592208,0.0183313,0.00004281921,0.001625097,0.0008076957,0.00004261677,0.00008328912,0.0001515094,0.01969493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4032714,"threshold_uncertainty_score":0.9998139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007615916104242205,"score_gpt":0.2096246413942286,"score_spread":0.2020087252899864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}