{"id":"W2803103630","doi":"10.1128/aac.00222-18","title":"High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Alberta Innovates Bio Solutions; Alberta Livestock and Meat Agency","keywords":"Ursodeoxycholic acid; Medicine; Neuroprotection; Bile acid; Internal medicine; Amyotrophic lateral sclerosis; Disease; Cirrhosis; Gastroenterology; Clinical trial; Apoptosis; Pharmacology; Endocrinology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004078959,0.0007784498,0.0006259466,0.001096539,0.0003388282,0.0004471381,0.0006141926,0.001108391,0.003266544],"category_scores_gemma":[0.0002147425,0.0003131811,0.0005330444,0.0003693441,0.0006206944,0.0005211867,0.0003107459,0.001586255,0.0009856265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004674501,"about_ca_system_score_gemma":0.0004571732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007345358,"about_ca_topic_score_gemma":0.001544212,"domain_scores_codex":[0.9994893,0.000102503,0.00005952494,0.0001389112,0.00008135923,0.0001282503],"domain_scores_gemma":[0.9994041,0.0000589673,0.0001791714,0.00009818529,0.00005412816,0.0002055276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002390621,0.0007900702,0.0003094102,0.00007554657,0.00002141023,0.0001191428,0.00005972545,0.00009438802,0.990923,0.0002903972,0.0002226933,0.00470358],"study_design_scores_gemma":[0.0002449323,0.007132969,0.002258049,0.0000232621,0.00003941684,0.0003505601,0.000047465,0.0006615027,0.9846532,0.0001096606,0.004463021,0.00001588872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848441,0.002607272,0.004490622,0.0005382609,0.0002684784,0.0002484675,0.002552046,0.000594363,0.003856287],"genre_scores_gemma":[0.9711316,0.001868264,0.007851351,0.0003250909,0.00007682354,0.0005802813,0.002098284,0.0001520822,0.01591629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003266544,"threshold_uncertainty_score":0.01092768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005163852128022475,"score_gpt":0.2362248970151749,"score_spread":0.2310610448871524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}