{"id":"W2803164013","doi":"10.1038/s41419-018-0672-0","title":"Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis","year":2018,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; National Research Council Canada; Institute of Infection and Immunity; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; King Saud University","keywords":"Necroptosis; RIPK1; Ubiquitin ligase; Ubiquitin; Cell biology; Programmed cell death; Inflammation; Downregulation and upregulation; Cytokine; Biology; Signal transduction; Chemistry; Cancer research; Apoptosis; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008342,0.0002876576,0.0003017652,0.0003539334,0.0002420062,0.0004577979,0.0002196468,0.0002712472,0.0022662],"category_scores_gemma":[0.0001466883,0.0001293498,0.000456986,0.0002091635,0.0003126376,0.0002953609,0.000270333,0.0006877259,0.000848432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005662531,"about_ca_system_score_gemma":0.0003381892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003846569,"about_ca_topic_score_gemma":0.0006392819,"domain_scores_codex":[0.9998325,0.00002379757,0.00002055191,0.00004047153,0.00003914836,0.00004364134],"domain_scores_gemma":[0.9998253,0.00002106733,0.00005157266,0.00003148806,0.00001892173,0.00005161084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001401632,0.00002330986,0.0001005313,0.00002797551,0.000006146759,0.00004285099,0.000005211719,0.00005115145,0.9985739,0.0001342757,0.00005989331,0.0008346014],"study_design_scores_gemma":[0.00001801003,0.0001180111,0.001637246,0.000002644015,0.000006302191,0.0003313341,0.00001317152,0.0005601564,0.9953532,0.00009154873,0.001864073,0.000004326796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799072,0.004419376,0.009817885,0.0004138531,0.0001266277,0.00005784385,0.00108112,0.0005030579,0.003673117],"genre_scores_gemma":[0.9925274,0.000765096,0.003256644,0.0001055545,0.00001067292,0.00003224022,0.0007117598,0.00005001737,0.002540686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022662,"threshold_uncertainty_score":0.007581174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330898060295509,"score_gpt":0.2329331251327205,"score_spread":0.2196241445297654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}