{"id":"W2803192810","doi":"10.1371/journal.pone.0197543","title":"Molecular effect of an OPTN common variant associated to Paget's disease of bone","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bone health and treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fundação para a Ciência e a Tecnologia; Fonds de Recherche du Québec - Santé; Centro de Ciências do Mar; Université Laval","keywords":"Protein Data Bank (RCSB PDB); Optineurin; Paget's disease of bone; Genetics; Biology; Pathogenesis; Locus (genetics); Gene; Sequestosome 1; Allele; Phenotype; Mutation; Bioinformatics; Medicine; Disease; Immunology; Pathology; Biochemistry; Immunoglobulin light chain","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711495,0.0006584103,0.0004595678,0.0008121762,0.0003314094,0.0002566974,0.0002323113,0.0009367891,0.002640269],"category_scores_gemma":[0.000939107,0.0001567749,0.0005252716,0.0004692032,0.000401877,0.0001323968,0.0002493162,0.0003689446,0.0002172372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001836725,"about_ca_system_score_gemma":0.0001537672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082402,"about_ca_topic_score_gemma":0.0008202998,"domain_scores_codex":[0.9997329,0.00005213354,0.00004103192,0.0001018007,0.00004609363,0.00002598753],"domain_scores_gemma":[0.9994578,0.0001948487,0.0001852845,0.00002284322,0.00003266587,0.0001066051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00650841,0.0005788868,0.3959361,0.0003289088,0.0006736959,0.2353733,0.0005680451,0.0008477314,0.3443965,0.0008671558,0.0006439441,0.01327727],"study_design_scores_gemma":[0.0002641661,0.00167066,0.8071824,0.00005776048,0.0005418651,0.167503,0.0002067145,0.002615256,0.01765716,0.0007274486,0.001521132,0.00005244737],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986165,0.0003022899,0.000448045,0.00008274691,0.00002662244,0.00001265096,0.000170844,0.00001245847,0.0003278371],"genre_scores_gemma":[0.9991036,0.00007630439,0.0003919835,0.00004742553,0.00003442255,0.000004753092,0.0001033416,0.000006442934,0.0002316348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002640269,"threshold_uncertainty_score":0.008832633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02204378063108615,"score_gpt":0.2885181045464596,"score_spread":0.2664743239153735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}