{"id":"W2803225311","doi":"10.1016/j.celrep.2018.04.084","title":"Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome Canada","keywords":"Echinocandins; Echinocandin; Candida albicans; Biology; Corpus albicans; Mutant; Cell biology; Gene; Microbiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300556,0.0003582788,0.0002822003,0.0004325639,0.0001398265,0.0002310548,0.0002514954,0.0001774539,0.0007237818],"category_scores_gemma":[0.0001816987,0.0001401622,0.0002770294,0.0003692083,0.0001872378,0.00006525366,0.0001763652,0.0003175375,0.0002124449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002688179,"about_ca_system_score_gemma":0.0002603023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107351,"about_ca_topic_score_gemma":0.001836796,"domain_scores_codex":[0.9998903,0.00001386011,0.00001510184,0.00002132422,0.00003332365,0.00002593111],"domain_scores_gemma":[0.9998326,0.00004967887,0.00004943566,0.00001749957,0.00001812552,0.00003264166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006157929,0.00001830904,0.0002905289,0.00001520562,0.000003691126,0.00005400745,0.000006255013,0.00008607178,0.9985589,0.00002437612,0.00001220371,0.0008688732],"study_design_scores_gemma":[0.00002478683,0.0004676419,0.02366064,0.000008367986,0.00005285977,0.0005142016,0.00004591266,0.001108942,0.9727206,0.00005920081,0.001324973,0.00001190747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952086,0.0006149193,0.001966875,0.00005740412,0.000009312086,0.00004934858,0.00144854,0.00009872263,0.0005463873],"genre_scores_gemma":[0.9940824,0.0004202629,0.002249753,0.00006005632,0.000006045544,0.00003157625,0.002555269,0.00003247746,0.0005621489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001107351,"threshold_uncertainty_score":0.00242126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03564670043168457,"score_gpt":0.2866976519617657,"score_spread":0.2510509515300811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}