{"id":"W2803293238","doi":"10.1111/bph.14200","title":"Heat shock protein‐27 and sex‐selective regulation of muscarinic and proteinase‐activated receptor 2‐mediated vasodilatation: differential sensitivity to endothelial NOS inhibition","year":2018,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Weill Cornell Medicine - Qatar; University of Hong Kong; Heart and Stroke Foundation of Canada; University of Calgary","keywords":"Internal medicine; Endocrinology; Enos; Endothelial NOS; Receptor; Agonist; Hsp27; Heat shock protein; Muscarinic acetylcholine receptor; Vasodilation; Phenylephrine; Endothelial dysfunction; Chemistry; Biology; Nitric oxide; Medicine; Hsp70; Nitric oxide synthase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104982,0.0002464513,0.000214965,0.0001632753,0.0001034931,0.0001611509,0.0001115734,0.0001756538,0.002045301],"category_scores_gemma":[0.00009699536,0.0001465754,0.0002920606,0.00007724976,0.0002013855,0.0001093745,0.0001728982,0.0003820092,0.0002082525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772587,"about_ca_system_score_gemma":0.0001343876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002902043,"about_ca_topic_score_gemma":0.0004689613,"domain_scores_codex":[0.9998857,0.0000181222,0.00000757727,0.00002803541,0.00002386411,0.00003667095],"domain_scores_gemma":[0.9998828,0.000009568661,0.00004037992,0.0000113143,0.00001379061,0.00004203675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000273847,0.00001784969,0.0002679619,0.00002502435,0.000006604833,0.00003312625,0.000008558139,0.00001256597,0.9984876,0.00003042596,0.00002471387,0.0008116712],"study_design_scores_gemma":[0.00003401947,0.0007002849,0.05332922,0.000008718294,0.00003907705,0.000387966,0.00005218938,0.0002714625,0.9434772,0.00004102201,0.001651412,0.000007613374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950998,0.002634183,0.001006254,0.00009799841,0.0000305148,0.00001651312,0.0003609975,0.00003139518,0.0007222532],"genre_scores_gemma":[0.9953661,0.001227342,0.0004872305,0.00008082533,0.0000163815,0.0000379167,0.0003824265,0.00001265055,0.002389132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002045301,"threshold_uncertainty_score":0.006842196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008596989116122885,"score_gpt":0.2603238548878289,"score_spread":0.2517268657717061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}