{"id":"W2803378787","doi":"10.1016/j.molmet.2018.05.013","title":"PPARγ is dispensable for clear cell renal cell carcinoma progression","year":2018,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Clear cell renal cell carcinoma; Biology; Cancer research; Peroxisome proliferator-activated receptor; Chromatin immunoprecipitation; Carcinogenesis; Nuclear receptor; Cell growth; Cell biology; Transcription factor; Cancer; Receptor; Internal medicine; Renal cell carcinoma; Gene expression; Medicine; Biochemistry; Genetics; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002052016,0.0003477837,0.0002954447,0.00008116647,0.0002111319,0.00006527828,0.0003921039,0.0002811922,0.0001318744],"category_scores_gemma":[0.00004486525,0.0003177208,0.0002466844,0.000179579,0.0001648555,0.00001098412,0.0002116672,0.000154394,0.00009959358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001732211,"about_ca_system_score_gemma":0.0001186516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001297751,"about_ca_topic_score_gemma":0.000001984211,"domain_scores_codex":[0.9979495,0.0001053538,0.0002969697,0.0007606829,0.0002708044,0.000616704],"domain_scores_gemma":[0.9986722,0.000006672448,0.0001528464,0.0006847415,0.0002584635,0.0002251062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002384934,0.0001362702,0.0002733446,0.00003304878,0.00003197939,0.000004063193,0.00008146205,0.000002750178,0.9878487,0.00003894965,0.01037993,0.0009310176],"study_design_scores_gemma":[0.001008854,0.0003266423,0.0001471711,0.000006498437,0.00005074241,0.000004628319,0.00001959553,0.000069186,0.7459876,0.00006146987,0.2520322,0.0002854185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870052,0.003020361,0.005681737,0.0001508687,0.0004821998,0.0006410801,0.00006158115,0.00003662655,0.002920322],"genre_scores_gemma":[0.9894053,0.00005829331,0.00691547,0.0009473579,0.0007763092,0.0001284702,0.0001478574,0.0001081737,0.001512803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2418611,"threshold_uncertainty_score":0.9999275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007608597320384014,"score_gpt":0.254507869985275,"score_spread":0.246899272664891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}