{"id":"W2803378787","doi":"10.1016/j.molmet.2018.05.013","title":"PPARγ is dispensable for clear cell renal cell carcinoma progression","year":2018,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Clear cell renal cell carcinoma; Biology; Cancer research; Peroxisome proliferator-activated receptor; Chromatin immunoprecipitation; Carcinogenesis; Nuclear receptor; Cell growth; Cell biology; Transcription factor; Cancer; Receptor; Internal medicine; Renal cell carcinoma; Gene expression; Medicine; Biochemistry; Genetics; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002961959,0.0003072793,0.0004985425,0.0004234871,0.0004373144,0.0009261134,0.0004609764,0.0004096313,0.004520816],"category_scores_gemma":[0.0003786204,0.0002907113,0.0005913089,0.0003695512,0.000481824,0.0003325602,0.0005742309,0.0008752312,0.001922531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005588215,"about_ca_system_score_gemma":0.001008167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00301767,"about_ca_topic_score_gemma":0.003181171,"domain_scores_codex":[0.9995446,0.0000412051,0.00004084563,0.0001321418,0.0001696227,0.00007154528],"domain_scores_gemma":[0.9994407,0.00007871813,0.0001623825,0.00009997408,0.0001002971,0.0001178024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002875592,0.00003153313,0.002275831,0.0001475233,0.00002130285,0.0003002103,0.00005991576,0.0002325297,0.9916688,0.000590922,0.0003022748,0.004081701],"study_design_scores_gemma":[0.00008183881,0.0003709032,0.05383581,0.00007639223,0.0001280968,0.003765444,0.0003799425,0.003304223,0.9019631,0.0007008064,0.03534372,0.00004980181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697287,0.00795144,0.01078579,0.0005476142,0.000122682,0.00005107489,0.003227194,0.0007590606,0.006826436],"genre_scores_gemma":[0.9895986,0.001641569,0.001880526,0.0001931765,0.00001240632,0.00004035891,0.00198397,0.0001068251,0.00454266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004520816,"threshold_uncertainty_score":0.01512361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007608597320384014,"score_gpt":0.254507869985275,"score_spread":0.246899272664891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}