{"id":"W2803401207","doi":"10.1113/jp275877","title":"Shared and unique aspects of ligand‐ and voltage‐gated ion‐channel gating","year":2018,"lang":"en","type":"editorial","venue":"The Journal of Physiology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Gating; Ion channel; Neuroscience; Ligand-gated ion channel; Voltage-gated ion channel; Biophysics; Chemistry; Cognitive science; Biology; Psychology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007492764,0.0002459337,0.0005772053,0.00005971194,0.00008048559,0.000009053338,0.0003586837,0.0005634169,0.000009491485],"category_scores_gemma":[0.0009760999,0.0001647098,0.00009452907,0.00006518693,0.0003604709,0.000004869036,0.0003577316,0.0005538535,9.887749e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001289312,"about_ca_system_score_gemma":0.0002380258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002668158,"about_ca_topic_score_gemma":0.00001605161,"domain_scores_codex":[0.9985864,0.0002679407,0.0005324964,0.0002227031,0.000185237,0.0002052565],"domain_scores_gemma":[0.9977124,0.0002701741,0.001101128,0.0002745497,0.0005681767,0.00007352496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002813942,0.00003397408,0.00000531734,0.00005860483,0.0002191601,3.098764e-7,0.0001547998,0.000003977066,0.7475241,0.000004473009,0.2516502,0.00006368964],"study_design_scores_gemma":[0.002452365,0.004497206,0.0002406928,0.0003676141,0.0003775513,0.00009897343,0.000367336,0.00002661746,0.8720287,0.001248547,0.1178688,0.0004255929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8768626,0.00318059,0.00007507975,0.000080243,0.1193525,0.0002078424,0.00007272854,0.000004689844,0.0001637803],"genre_scores_gemma":[0.6843842,0.003146388,0.00009146542,0.00003334997,0.3121063,0.00000151617,0.00006932675,0.00004283281,0.0001246572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1927538,"threshold_uncertainty_score":0.6716669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007079676403123152,"score_gpt":0.2609867007125665,"score_spread":0.2539070243094433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}