{"id":"W2803421065","doi":"10.14745/ccdr.v41i08a03","title":"Propagated protein misfolding: New opportunities for therapeutics, new public health risk","year":2015,"lang":"en","type":"article","venue":"Canada Communicable Disease Report","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chronic wasting disease; Scrapie; Disease; Amyotrophic lateral sclerosis; Bovine spongiform encephalopathy; Mechanism (biology); Prion protein; Transmissible spongiform encephalopathy; Protein folding; Neurodegeneration; Biology; Virology; Neuroscience; Medicine; Bioinformatics; Pathology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005550767,0.0007790004,0.001564723,0.001262454,0.001134944,0.004440816,0.001202543,0.007290324,0.01897602],"category_scores_gemma":[0.005075749,0.0003509044,0.0007575391,0.0008084903,0.005532627,0.008084196,0.002225809,0.00537786,0.002623096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002103826,"about_ca_system_score_gemma":0.004023137,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008384858,"about_ca_topic_score_gemma":0.001891317,"domain_scores_codex":[0.9983388,0.0006660597,0.0001124948,0.0001824736,0.0005241987,0.0001759351],"domain_scores_gemma":[0.993459,0.003593,0.0004913426,0.0004979489,0.001097211,0.0008614068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000949432,0.000658471,0.00309959,0.003612684,0.0001647159,0.003100573,0.0006768903,0.001526623,0.006621874,0.2418026,0.1635869,0.5741997],"study_design_scores_gemma":[0.0002052888,0.0009768168,0.002015284,0.002126643,0.0001164272,0.003320076,0.001539094,0.0009933701,0.001935977,0.267693,0.7189608,0.0001170466],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.003972299,0.6016665,0.007564575,0.3581617,0.004167607,0.00003721124,0.00019839,0.0001958193,0.02403587],"genre_scores_gemma":[0.09923156,0.7787721,0.01210834,0.07367514,0.02169198,0.0001518417,0.0002683814,0.00008550388,0.01401504],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9991615,"threshold_uncertainty_score":0.06348103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1903952529430582,"score_gpt":0.3097501993542113,"score_spread":0.1193549464111532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}