{"id":"W2803424141","doi":"10.1186/s13048-018-0399-7","title":"Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer","year":2018,"lang":"en","type":"article","venue":"Journal of Ovarian Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Ontario Institute for Cancer Research","funders":"Ontario Ministry of Research, Innovation and Science; Government of Ontario","keywords":"Paclitaxel; Ovarian cancer; Spindle checkpoint; Cancer research; BUB1; Docetaxel; Medicine; Oncology; Cancer; Biology; Internal medicine; Spindle apparatus; Cell; Kinetochore; Gene; Genetics; Cell division","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007449675,0.0001059604,0.0001371084,0.0004075702,0.0001151353,0.000207457,0.00006655537,0.0001311839,0.0009987558],"category_scores_gemma":[0.0001646205,0.00007774356,0.00008534113,0.0002518707,0.0001086529,0.00007412393,0.00007763629,0.0002030003,0.0001773852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001526171,"about_ca_system_score_gemma":0.00009983049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004106363,"about_ca_topic_score_gemma":0.0005767231,"domain_scores_codex":[0.9999572,0.000006176543,0.000005401279,0.00001176456,0.00001151871,0.000007913039],"domain_scores_gemma":[0.9998719,0.00001645636,0.00007122057,0.00001103882,0.00001294235,0.00001631239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003912279,0.00007607101,0.03519917,0.00004425869,0.00002457377,0.0004928986,0.00005027627,0.0001994235,0.9579209,0.0001673828,0.0002357452,0.005198131],"study_design_scores_gemma":[0.00006140841,0.0007107703,0.6088871,0.00001798213,0.0001022104,0.005999593,0.0001614308,0.002782785,0.3733096,0.0002901674,0.007662371,0.00001443984],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981711,0.0005917101,0.000482654,0.00004315702,0.000004291149,0.00001177228,0.0002024272,0.00002634548,0.0004665597],"genre_scores_gemma":[0.9981722,0.0005109753,0.0002347359,0.00002072273,0.000003415361,0.000009922708,0.0004231382,0.000004892652,0.000619887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009987558,"threshold_uncertainty_score":0.003341198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03364327789474853,"score_gpt":0.339943190352653,"score_spread":0.3062999124579044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}