{"id":"W2803475099","doi":"10.1002/pep2.24077","title":"Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity","year":2018,"lang":"en","type":"article","venue":"Peptide Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Peptide; In vivo; Chemistry; Excipient; In vitro; Biocompatible material; Biochemistry; Biology; Chromatography; Medicine; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006306006,0.000126386,0.0001100532,0.0001067817,0.0002427257,0.0000686785,0.0003011649,0.00007067783,0.000007960442],"category_scores_gemma":[0.0001221271,0.000123883,0.00003988049,0.0001766628,0.0004614036,0.0001423665,0.0001287317,0.00005420501,0.000008410668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003664563,"about_ca_system_score_gemma":0.0001359977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001508678,"about_ca_topic_score_gemma":0.0002136392,"domain_scores_codex":[0.9987592,0.00004751658,0.0002202822,0.0004674273,0.0002792162,0.0002263543],"domain_scores_gemma":[0.9988715,0.000006759088,0.0002548465,0.000470439,0.0003118137,0.00008465518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006253408,0.0000410848,0.01749526,0.00001048263,0.000008134512,1.556754e-7,0.0001929625,0.00002123114,0.9731645,0.00002769496,0.00005691753,0.008919064],"study_design_scores_gemma":[0.0001800711,0.0002670808,0.3037584,0.00001855179,0.000009220465,0.000003213573,0.00005234506,0.002024366,0.6933001,0.0001548181,0.0001188315,0.0001130467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978989,0.00004778146,0.001302217,0.00002023832,0.000132416,0.0001962516,0.00001741701,0.00001030656,0.000374516],"genre_scores_gemma":[0.9990125,0.00005584875,0.0002684551,0.00003660022,0.00009377087,0.000009288752,0.00003987243,0.000009521036,0.0004741469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2862631,"threshold_uncertainty_score":0.5051802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409023553113829,"score_gpt":0.2782946666711593,"score_spread":0.264204431140021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}