{"id":"W2803475099","doi":"10.1002/pep2.24077","title":"Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity","year":2018,"lang":"en","type":"article","venue":"Peptide Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Peptide; In vivo; Chemistry; Excipient; In vitro; Biocompatible material; Biochemistry; Biology; Chromatography; Medicine; Biomedical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550693,0.0002861253,0.0002139532,0.0002113886,0.00006090161,0.000254271,0.0001437259,0.0002076818,0.0006979613],"category_scores_gemma":[0.000173373,0.00006929118,0.0001360846,0.0001356886,0.0001084793,0.000141315,0.0001127739,0.0002321508,0.0002316197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001786187,"about_ca_system_score_gemma":0.0001402997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001529091,"about_ca_topic_score_gemma":0.0002230966,"domain_scores_codex":[0.9999037,0.00001517773,0.000009631796,0.00002160633,0.00003162189,0.00001829649],"domain_scores_gemma":[0.9999207,0.00001241295,0.00002939279,0.000006738931,0.00001322112,0.00001742399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002810319,0.00001841955,0.00008450803,0.00002310953,0.000001668591,0.00003361292,0.00000303764,0.00008070336,0.9983001,0.00001936083,0.000009983613,0.001397294],"study_design_scores_gemma":[0.00001259511,0.0004914342,0.001151803,0.000004404524,0.00001165446,0.0001957385,0.000008581806,0.0008706643,0.9958408,0.000008868316,0.001399998,0.000003385262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926917,0.001053521,0.004945817,0.00004805711,0.00001354582,0.00009649044,0.000189459,0.00003985663,0.000921627],"genre_scores_gemma":[0.9830945,0.0006099382,0.01434899,0.00005498794,0.00001046622,0.00005579222,0.0004117131,0.00001851239,0.001395118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006979613,"threshold_uncertainty_score":0.002334952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409023553113829,"score_gpt":0.2782946666711593,"score_spread":0.264204431140021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}