{"id":"W2803475892","doi":"10.1016/j.scr.2018.05.005","title":"Metabolic plasticity during transition to naïve-like pluripotency in canine embryo-derived stem cells","year":2018,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Induced pluripotent stem cell; Embryonic stem cell; Cell biology; Oxidative phosphorylation; Stem cell; Leukemia inhibitory factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001481127,0.0003448069,0.0003955094,0.0006581359,0.0003864822,0.0001091435,0.0008389751,0.0003181504,0.000153541],"category_scores_gemma":[0.00002361925,0.0003471945,0.000129401,0.001101954,0.0002535719,0.00001899431,0.0005811792,0.0006202817,0.0007133543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001591009,"about_ca_system_score_gemma":0.0004011891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004811861,"about_ca_topic_score_gemma":0.0009572788,"domain_scores_codex":[0.9946235,0.0007915464,0.0005313173,0.001179721,0.001252486,0.001621412],"domain_scores_gemma":[0.9978948,0.00008325325,0.00006260533,0.0007430802,0.0006562056,0.0005600353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006373767,0.0001834475,0.000156223,0.0001726044,0.00003208685,0.00008623561,0.0005675953,0.0002699238,0.9959599,0.00001143456,0.0008664766,0.001056738],"study_design_scores_gemma":[0.001301028,0.000712258,0.003765441,0.00006502152,0.00000825437,0.00001437816,0.0006421798,0.0003742235,0.9864143,0.000007720647,0.006336026,0.0003591503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932702,0.0006342455,0.0005410369,0.0002131898,0.0002259579,0.00115193,0.00006336762,0.00003131843,0.003868771],"genre_scores_gemma":[0.9873509,0.0003954418,0.0001772872,0.00006688143,0.0004793098,0.0001494032,0.00002663625,0.00008318412,0.01127091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009545539,"threshold_uncertainty_score":0.999898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02660745866654213,"score_gpt":0.2951316564175954,"score_spread":0.2685241977510533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}