{"id":"W2803492840","doi":"10.1038/s41416-018-0108-8","title":"Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer","year":2018,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Groupement des Entreprises Françaises dans la lutte contre le Cancer; National Institutes of Health; Florida Department of Health; Centre Hospitalier Universitaire de Nantes; Cancer Council Victoria; Deutsche Krebshilfe; Ministerio de Economía y Competitividad; Deutsche Forschungsgemeinschaft; Broad Institute; University of South Florida; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Bundesministerium für Bildung und Forschung; Association Anne de Bretagne Genetique; National Institute on Aging; Division of Cancer Prevention, National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Moffitt Cancer Center; National Health and Medical Research Council; American Cancer Society; Centers for Disease Control and Prevention; Génome Québec; Conseil Régional des Pays de la Loire; Ontario Institute for Cancer Research; U.S. Department of Health and Human Services","keywords":"Menarche; Odds ratio; Medicine; Menopause; Confidence interval; Confounding; Internal medicine; Body mass index; Oncology; Colorectal cancer; Gynecology; Demography; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001310173,0.0001134295,0.0006906842,0.00007541223,0.0001112563,0.00001500358,0.0000789248,0.00004376739,0.0001188192],"category_scores_gemma":[0.0003687979,0.00008161196,0.0000683535,0.00009099334,0.0006205822,0.0000893195,0.00008210681,0.0001847059,2.549288e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162097,"about_ca_system_score_gemma":0.00008989746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003716247,"about_ca_topic_score_gemma":0.01543882,"domain_scores_codex":[0.9984378,0.0002742051,0.0005353984,0.0001795598,0.0004318311,0.0001411805],"domain_scores_gemma":[0.9984443,0.000190947,0.0007035921,0.0001246392,0.0004494757,0.00008704994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.07315622,0.0006612627,0.3291499,0.0002086633,0.005100804,0.0006972436,0.02747928,0.00004385357,0.3891401,0.00001201942,0.002412864,0.1719377],"study_design_scores_gemma":[0.06960621,0.00198173,0.9071558,0.0003933072,0.001910638,0.001168847,0.00115812,0.00005996825,0.01465256,0.0001330446,0.001652685,0.00012705],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695942,0.02879456,0.000006453889,0.0005109988,0.000157488,0.0007001447,0.00003022614,0.000003362543,0.0002025804],"genre_scores_gemma":[0.9853701,0.01372604,0.00008723671,0.00004062981,0.0003418667,0.00002518899,6.265095e-7,0.00001665683,0.0003916339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5780059,"threshold_uncertainty_score":0.8615226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423097618850248,"score_gpt":0.2854341334764839,"score_spread":0.2712031572879814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}