{"id":"W2803492840","doi":"10.1038/s41416-018-0108-8","title":"Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer","year":2018,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Groupement des Entreprises Françaises dans la lutte contre le Cancer; National Institutes of Health; Florida Department of Health; Centre Hospitalier Universitaire de Nantes; Cancer Council Victoria; Deutsche Krebshilfe; Ministerio de Economía y Competitividad; Deutsche Forschungsgemeinschaft; Broad Institute; University of South Florida; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Bundesministerium für Bildung und Forschung; Association Anne de Bretagne Genetique; National Institute on Aging; Division of Cancer Prevention, National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Moffitt Cancer Center; National Health and Medical Research Council; American Cancer Society; Centers for Disease Control and Prevention; Génome Québec; Conseil Régional des Pays de la Loire; Ontario Institute for Cancer Research; U.S. Department of Health and Human Services","keywords":"Menarche; Odds ratio; Medicine; Menopause; Confidence interval; Confounding; Internal medicine; Body mass index; Oncology; Colorectal cancer; Gynecology; Demography; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05060491,0.001723793,0.003097614,0.00167544,0.0008459818,0.001035042,0.002069036,0.0023357,0.004732664],"category_scores_gemma":[0.1259027,0.001070187,0.0038827,0.001800903,0.00153992,0.0007791908,0.0008517015,0.001319894,0.000437686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001608447,"about_ca_system_score_gemma":0.001724777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004105585,"about_ca_topic_score_gemma":0.002428066,"domain_scores_codex":[0.938128,0.05236549,0.002602472,0.003707441,0.002307079,0.0008894769],"domain_scores_gemma":[0.9486059,0.03087041,0.00690253,0.01137158,0.001611543,0.000638093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3035971,0.003475483,0.4155136,0.007062463,0.08971982,0.006500866,0.002466797,0.02273581,0.008973308,0.03781715,0.01220757,0.08993018],"study_design_scores_gemma":[0.2424827,0.06332565,0.2897304,0.002113024,0.1013271,0.01295429,0.0007636557,0.1635178,0.007330735,0.08662565,0.0289034,0.0009256459],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7712432,0.01086205,0.1817943,0.001277023,0.00109512,0.02627869,0.00330911,0.0006036825,0.003536866],"genre_scores_gemma":[0.9371904,0.001191128,0.04106873,0.0006594721,0.0001191777,0.01606941,0.001523737,0.00005700404,0.002120947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05060491,"threshold_uncertainty_score":0.2676275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423097618850248,"score_gpt":0.2854341334764839,"score_spread":0.2712031572879814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}