{"id":"W2803515629","doi":"10.1038/s41598-018-25487-5","title":"Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"National Research Council Canada; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Cancer Agency; University of Saskatchewan; Canadian Light Source; Canadian Institutes of Health Research; Saskatchewan Health Research Foundation; University of Oklahoma","keywords":"PTEN; GTPase; Phosphatase; Mutation; Tensin; Mutant; Carcinogenesis; Cancer research; Biology; Cell biology; PI3K/AKT/mTOR pathway; Signal transduction; Phosphorylation; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866738,0.0003832238,0.0002362905,0.0001564565,0.0001923799,0.000247591,0.0001621574,0.0004361394,0.001750589],"category_scores_gemma":[0.0003087428,0.0001318407,0.0003452761,0.0001804478,0.0003442447,0.0001497247,0.00019457,0.0004654404,0.0003157275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003382415,"about_ca_system_score_gemma":0.0002217919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006364411,"about_ca_topic_score_gemma":0.0008024375,"domain_scores_codex":[0.9997527,0.00005608627,0.00003825,0.00004477647,0.00006333166,0.00004490267],"domain_scores_gemma":[0.999891,0.00003020438,0.00002583427,0.00001610616,0.000008802199,0.0000279485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003998952,0.0002204268,0.005744928,0.00004764355,0.00006472579,0.002184201,0.00005453417,0.000964297,0.9854243,0.0004463613,0.0001525064,0.004296208],"study_design_scores_gemma":[0.0001087281,0.00120352,0.03253004,0.0000118746,0.000173278,0.01442729,0.00009936511,0.003062055,0.9431912,0.0002586063,0.004917828,0.00001611678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984034,0.0001485972,0.0005134388,0.00003390636,0.000009159465,0.0000155565,0.0001238081,0.00001715674,0.0007350321],"genre_scores_gemma":[0.9992698,0.00009166526,0.000246743,0.00002208509,0.000001943993,0.00000564128,0.00009460461,0.000004822532,0.0002626888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750589,"threshold_uncertainty_score":0.005856276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086203470388897,"score_gpt":0.2535173577841594,"score_spread":0.2426553230802704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}