{"id":"W2803528938","doi":"10.1158/1538-7445.mousemodels17-a29","title":"Abstract A29: Generation of a novel transgenic mouse model with regulatable β-catenin expression to examine importance of activated β-catenin signaling to long-term maintenance of mammary tumor growth","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Cre recombinase; Biology; Genetically modified mouse; Transgene; Catenin; Mammary tumor; Chimera (genetics); Tumor initiation; Carcinogenesis; Cancer research; Cell biology; Genetics; Wnt signaling pathway; Gene; Signal transduction; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005352033,0.001069494,0.0006987879,0.00150697,0.0005268415,0.0006505862,0.0009036053,0.001350867,0.006945811],"category_scores_gemma":[0.0002500034,0.000508251,0.0009101311,0.0004806978,0.0005713475,0.0006633717,0.0005496047,0.00239923,0.003670838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005448805,"about_ca_system_score_gemma":0.0005121668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000674428,"about_ca_topic_score_gemma":0.000982995,"domain_scores_codex":[0.9993673,0.000049789,0.00008346442,0.0002282362,0.0001834814,0.00008777279],"domain_scores_gemma":[0.9992787,0.00006591412,0.0002011219,0.00008018922,0.00008385424,0.0002902991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001412092,0.0001951694,0.0001195544,0.00003438288,0.00000776543,0.0001558146,0.00002498297,0.00004874458,0.9977981,0.0003329878,0.0001869145,0.0009544223],"study_design_scores_gemma":[0.0002174614,0.001836288,0.003369036,0.00005133967,0.00007333086,0.002189327,0.00006880853,0.001793398,0.9748453,0.000256668,0.01526454,0.00003461151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9322457,0.001696548,0.04649053,0.0008444741,0.0004987817,0.00121189,0.009606956,0.001306416,0.006098704],"genre_scores_gemma":[0.8633577,0.002793582,0.05247033,0.0005607,0.0001906605,0.002682141,0.01210495,0.001011969,0.06482797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006945811,"threshold_uncertainty_score":0.0232361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0802555236614484,"score_gpt":0.3439358210122373,"score_spread":0.2636802973507889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}