{"id":"W2803533112","doi":"10.1007/s40263-018-0526-4","title":"Systemic Therapy of Lung Cancer CNS Metastases Using Molecularly Targeted Agents and Immune Checkpoint Inhibitors","year":2018,"lang":"en","type":"review","venue":"CNS Drugs","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Ceritinib; Anaplastic lymphoma kinase; Alectinib; Pembrolizumab; Atezolizumab; Lung cancer; Crizotinib; Nivolumab; Epidermal growth factor receptor; Radiation therapy; Oncology; Immunotherapy; Cancer; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004836652,0.0006293303,0.002638367,0.0002954029,0.00009430978,0.0000320956,0.0001419925,0.0002325952,0.0001811939],"category_scores_gemma":[0.00004408542,0.0004330263,0.0008785981,0.0004004577,0.0001785656,0.00006223077,0.0001054275,0.0002573685,0.00000733061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215112,"about_ca_system_score_gemma":0.0005396907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006659236,"about_ca_topic_score_gemma":0.000002253967,"domain_scores_codex":[0.9972345,0.0003023201,0.00110171,0.0005780863,0.0004019096,0.0003814589],"domain_scores_gemma":[0.998052,0.00007660323,0.0008343735,0.0006662097,0.0001770943,0.0001936961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001753767,0.0009153759,0.0002455369,0.09132133,0.01858957,0.0004218366,0.001651352,0.000003145507,0.001129355,0.00005885347,0.001209715,0.8842785],"study_design_scores_gemma":[0.006463272,0.0007736342,0.0001054019,0.1444571,0.02339371,0.0009079823,0.0003746485,0.0001867781,0.004054445,0.00001626896,0.8178127,0.00145412],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0108096,0.9860269,0.00006479587,0.00002350984,0.0004361924,0.002108264,0.0004403365,0.00003613041,0.00005423571],"genre_scores_gemma":[0.003556249,0.9945761,0.0008137879,0.00004824537,0.0002550374,0.0001712739,0.00032682,0.0001241815,0.0001283289],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8828244,"threshold_uncertainty_score":0.9998121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05160550864221264,"score_gpt":0.3612285686345384,"score_spread":0.3096230599923258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}