{"id":"W2803548740","doi":"10.1128/jb.00215-18","title":"Pseudomonas aeruginosa Regulated Intramembrane Proteolysis: Protease MucP Can Overcome Mutations in the AlgO Periplasmic Protease To Restore Alginate Production in Nonmucoid Revertants","year":2018,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Biology; Periplasmic space; Protease; Proteolysis; Pseudomonas aeruginosa; Microbiology; Neutral protease; Pseudomonas; Pseudomonadaceae; Pseudomonadales; Mutation; Biochemistry; Enzyme; Genetics; Bacteria; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001713044,0.0003193184,0.0002068908,0.0001733297,0.0001183422,0.0002960988,0.0002382812,0.0002693279,0.001530929],"category_scores_gemma":[0.0002329794,0.00009959764,0.0001994125,0.0001090013,0.0001691735,0.0001434902,0.0003446667,0.0005219934,0.000335828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001881604,"about_ca_system_score_gemma":0.0002313681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004784284,"about_ca_topic_score_gemma":0.0006017797,"domain_scores_codex":[0.9998412,0.0000298446,0.00001595947,0.00002081662,0.00005779135,0.00003431635],"domain_scores_gemma":[0.9998995,0.00001682811,0.00002806581,0.00001225069,0.00001201846,0.00003137681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007529178,0.00005002692,0.00007792621,0.00001675603,0.000003558586,0.00007530349,0.000009798341,0.00003009146,0.998206,0.00006742833,0.00004622245,0.001341471],"study_design_scores_gemma":[0.00004476721,0.0007925128,0.004368233,0.00001210947,0.00001761905,0.0009949242,0.00005741616,0.001103758,0.9890038,0.00009272427,0.003504323,0.000007775384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956067,0.0007320329,0.001950824,0.0001960317,0.00005384444,0.00004058055,0.0001874635,0.00007463137,0.001157863],"genre_scores_gemma":[0.9954027,0.0002926982,0.001237976,0.00005445208,0.00000933067,0.00002574908,0.0002916419,0.00003529949,0.002650073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530929,"threshold_uncertainty_score":0.00512141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001232263635215,"score_gpt":0.248037798032717,"score_spread":0.2380254753963648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}