{"id":"W2803586475","doi":"10.1158/1078-0432.ccr-18-1089","title":"Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Tenovus; Cancer Research UK; Cancer Research Wales","keywords":"Oncolytic virus; Tropism; Virotherapy; Oncolytic adenovirus; Cancer research; Ex vivo; Biology; Genetic enhancement; In vivo; Adenoviridae; Transgene; Gene delivery; Integrin; Immunology; Immune system; Cell; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188719,0.0004165437,0.0001334269,0.0001803701,0.0001062104,0.0002378985,0.0001957303,0.0002306861,0.0008029557],"category_scores_gemma":[0.00007972005,0.0001169613,0.0001798571,0.0001286451,0.0001727342,0.0001858752,0.0001502042,0.0003179395,0.000302937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004079962,"about_ca_system_score_gemma":0.0002998458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005082396,"about_ca_topic_score_gemma":0.0005464439,"domain_scores_codex":[0.9999056,0.00001360647,0.00001291835,0.00001665787,0.0000329356,0.00001842746],"domain_scores_gemma":[0.9999505,0.000004645057,0.00001407708,0.000007281877,0.000007986122,0.00001548788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007748943,0.00002806031,0.0001885375,0.00002531257,0.00000328363,0.0000289962,0.00000922353,0.0001055484,0.9981243,0.0001759652,0.00004146548,0.001191779],"study_design_scores_gemma":[0.00003339501,0.0005043596,0.001308448,0.000005915767,0.0000167755,0.0004294596,0.00001370331,0.001389208,0.9907385,0.00005639326,0.00549955,0.000004252447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861186,0.001307487,0.009747976,0.00008744259,0.00005065918,0.0001247691,0.0003871011,0.0001283932,0.00204754],"genre_scores_gemma":[0.9895625,0.0006670369,0.006813974,0.00003715965,0.000007755006,0.00004437375,0.000483849,0.00001836066,0.00236512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008029557,"threshold_uncertainty_score":0.002960205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1777316418186462,"score_gpt":0.5172641653514678,"score_spread":0.3395325235328216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}