{"id":"W2803586475","doi":"10.1158/1078-0432.ccr-18-1089","title":"Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Tenovus; Cancer Research UK; Cancer Research Wales","keywords":"Oncolytic virus; Tropism; Virotherapy; Oncolytic adenovirus; Cancer research; Ex vivo; Biology; Genetic enhancement; In vivo; Adenoviridae; Transgene; Gene delivery; Integrin; Immunology; Immune system; Cell; Virus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00402511,0.000346149,0.0005325946,0.0002120509,0.0005597515,0.0001264478,0.001183047,0.0005789784,0.000695343],"category_scores_gemma":[0.001265631,0.0002946079,0.0003851765,0.000600504,0.001831342,0.0000138966,0.0004090093,0.001156139,0.0001385194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116804,"about_ca_system_score_gemma":0.002775228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001254318,"about_ca_topic_score_gemma":0.01008529,"domain_scores_codex":[0.9945622,0.001131827,0.0007201892,0.001306282,0.0008678539,0.001411631],"domain_scores_gemma":[0.996029,0.0005942239,0.0001450274,0.0008568536,0.001920304,0.0004545847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06833492,0.0008067897,0.00255315,0.0001002212,0.001136038,0.00001200649,0.0005496984,0.00004295225,0.639456,0.0003923404,0.03559585,0.25102],"study_design_scores_gemma":[0.009244281,0.03058553,0.004236415,0.0001421033,0.0000643346,0.00000581691,0.0003007994,0.0005417686,0.6515461,0.002640432,0.2998593,0.0008331641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849871,0.00486433,0.0009517229,0.003870975,0.0008082206,0.002118465,0.0003860256,0.00004494171,0.001968242],"genre_scores_gemma":[0.9789418,0.00458278,0.000233932,0.001092678,0.007850735,0.002215456,0.00003727869,0.0001284955,0.004916836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2642634,"threshold_uncertainty_score":0.9999506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1777316418186462,"score_gpt":0.5172641653514678,"score_spread":0.3395325235328216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}