{"id":"W2803591712","doi":"10.1016/j.jpba.2018.05.019","title":"Probing DNA damage induced by common antiviral agents using multiple analytical techniques","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Hyperchromicity; Ledipasvir; DNA; DNA damage; Sofosbuvir; Daclatasvir; Guanine; Biochemistry; Ribavirin; Nucleotide; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006698484,0.0002222202,0.0007879754,0.0006228571,0.0001429015,0.00004502483,0.0001220487,0.0001584235,0.0002809939],"category_scores_gemma":[0.0001157817,0.0001408708,0.0003427337,0.001264789,0.0004563987,0.0001363485,0.0001016115,0.0004004384,0.000008445539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001071804,"about_ca_system_score_gemma":0.00009125912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001187474,"about_ca_topic_score_gemma":0.000003568016,"domain_scores_codex":[0.9977848,0.0001126341,0.0007754155,0.0002475636,0.0007223349,0.0003572368],"domain_scores_gemma":[0.9986948,0.0001100267,0.000223744,0.0001159768,0.0001952515,0.0006601514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001581646,0.00448954,0.324896,0.0001859475,0.01410266,0.001257715,0.0007272181,1.720318e-7,0.4572635,0.00004742224,0.009300955,0.1861472],"study_design_scores_gemma":[0.01700017,0.003798995,0.0421478,0.001032767,0.05013106,0.0008403174,0.0007334972,0.3523177,0.4157496,0.0002705879,0.114435,0.001542518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928359,0.00009721386,0.002436835,0.004154646,0.00006388834,0.000138599,0.00001019571,0.00002420826,0.0002384701],"genre_scores_gemma":[0.9953455,0.00008135618,0.003424301,0.0005173326,0.0003451006,0.000001453075,0.00002649128,0.00001268084,0.0002457914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3523175,"threshold_uncertainty_score":0.5744545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05732490418096418,"score_gpt":0.385277620820287,"score_spread":0.3279527166393228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}