{"id":"W2803591712","doi":"10.1016/j.jpba.2018.05.019","title":"Probing DNA damage induced by common antiviral agents using multiple analytical techniques","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Hyperchromicity; Ledipasvir; DNA; DNA damage; Sofosbuvir; Daclatasvir; Guanine; Biochemistry; Ribavirin; Nucleotide; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00112644,0.001132593,0.0005374014,0.001922322,0.001009465,0.0006853029,0.0007669769,0.001645686,0.001221862],"category_scores_gemma":[0.001324355,0.0005645776,0.0007500244,0.0008661234,0.0007804887,0.0007571703,0.000997551,0.001720516,0.000523893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004779969,"about_ca_system_score_gemma":0.000557694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005391792,"about_ca_topic_score_gemma":0.002176839,"domain_scores_codex":[0.9982051,0.0003743955,0.00008678378,0.0005111861,0.0006242351,0.0001983392],"domain_scores_gemma":[0.9987333,0.0003260274,0.000336173,0.000151509,0.0003724704,0.00008053782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006862885,0.00002172788,0.0007058983,0.00007473935,0.00005089835,0.00003397459,0.00005159168,0.0000508366,0.9943439,0.00009155842,0.00004952569,0.004456851],"study_design_scores_gemma":[0.000004550862,0.0002215657,0.002487176,0.00001190297,0.00008198159,0.0003155509,0.0000818434,0.0007558072,0.9946195,0.0001221931,0.001280846,0.00001711302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7326333,0.01713657,0.2379016,0.0009254707,0.0005180915,0.0003427764,0.0007358553,0.001124643,0.00868168],"genre_scores_gemma":[0.8233652,0.006663129,0.1601287,0.0008546117,0.0001001912,0.0003334523,0.0004492722,0.00009557953,0.008009851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001922322,"threshold_uncertainty_score":0.005957246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05732490418096418,"score_gpt":0.385277620820287,"score_spread":0.3279527166393228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}