{"id":"W2803650666","doi":"10.1038/s41419-018-0607-9","title":"Tamoxifen-induced knockdown of the mitochondrial calcium uniporter in Thy1-expressing neurons protects mice from hypoxic/ischemic brain injury","year":2018,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"Multiple Sclerosis Society; Multiple Sclerosis Society of Canada; Heart and Stroke Foundation of Canada; European Genomic Institute for Diabetes; Fondation Brain Canada; National Institute of General Medical Sciences; American Heart Association","keywords":"Uniporter; Gene knockdown; Neuroprotection; Mitochondrion; Gene silencing; Biology; Forebrain; Programmed cell death; Neuroscience; Cell biology; Apoptosis; Cytosol; Biochemistry; Central nervous system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005351398,0.000169119,0.000148468,0.0000386112,0.00009015486,0.00001915931,0.0001756267,0.0001588241,0.00005697816],"category_scores_gemma":[0.0002640729,0.0001328351,0.00008671659,0.00008375719,0.0001288356,0.000006606885,0.0001540626,0.0001287167,0.000007513869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006421736,"about_ca_system_score_gemma":0.0001859934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007573552,"about_ca_topic_score_gemma":0.00003113663,"domain_scores_codex":[0.998883,0.0001506374,0.0002206725,0.0004206864,0.0000966211,0.0002283763],"domain_scores_gemma":[0.9991587,0.00002335644,0.000102467,0.0004327151,0.00004862843,0.0002341666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006934968,0.00007897844,0.003765846,0.00001755003,0.000006177452,0.00000557595,0.00008060516,0.000001369641,0.9902511,0.00000572594,0.004701842,0.0003916963],"study_design_scores_gemma":[0.001327827,0.0002050867,0.00929702,0.00003236115,0.00003543666,0.000002575532,0.00002942921,0.00005680336,0.9693823,0.0002310836,0.01919216,0.0002078725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967819,0.0003030183,0.0003614684,0.0002348176,0.0007205873,0.0003766186,0.0001013334,0.000008843522,0.001111381],"genre_scores_gemma":[0.9970544,0.00001239268,0.0002396304,0.001147428,0.0007304507,0.00003149659,0.00007136593,0.00001866691,0.0006941448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02086879,"threshold_uncertainty_score":0.5416859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01557140466037934,"score_gpt":0.2470274699721221,"score_spread":0.2314560653117428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}