{"id":"W2803685378","doi":"10.3389/fnsyn.2018.00015","title":"Modeling Neurological Diseases With Human Brain Organoids","year":2018,"lang":"en","type":"review","venue":"Frontiers in Synaptic Neuroscience","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Organoid; Neuroscience; Human brain; Induced pluripotent stem cell; Human disease; Brain function; Disease; Computer science; Medicine; Biology; Pathology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003472114,0.0004752448,0.0008643927,0.0002727063,0.0001992314,0.00009669286,0.001464488,0.0003163776,0.00000624207],"category_scores_gemma":[0.0003952109,0.000356233,0.0001946016,0.0006283603,0.0008086492,0.00001039374,0.0005899956,0.000446879,0.00001132363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004149432,"about_ca_system_score_gemma":0.0003563098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004113205,"about_ca_topic_score_gemma":0.000004642175,"domain_scores_codex":[0.9963162,0.0004194114,0.0004615979,0.001539893,0.0004897776,0.000773149],"domain_scores_gemma":[0.9986714,0.00002440117,0.0001327227,0.0008755838,0.00005807145,0.0002378659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001384108,0.005195882,0.01673286,0.04998974,0.0009750901,0.009084337,0.0002222993,0.01058423,0.03459736,0.0003207272,0.1456627,0.7252507],"study_design_scores_gemma":[0.0005989491,0.002487695,0.00006701086,0.001756198,0.0002107788,0.0003231126,0.00001359149,0.01387545,0.00004031603,0.00007221843,0.9792071,0.001347574],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004604258,0.9826729,0.01086549,0.00005111491,0.000719349,0.0008745934,0.0000458797,0.00003760955,0.0001288289],"genre_scores_gemma":[0.003236238,0.994362,0.0008043264,0.000308949,0.000240963,0.0001221062,0.00008262178,0.00009217791,0.0007505938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8335444,"threshold_uncertainty_score":0.999889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03302360442847191,"score_gpt":0.311841612102574,"score_spread":0.2788180076741021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}