{"id":"W2803704419","doi":"10.1172/jci.insight.120365","title":"Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control","year":2018,"lang":"en","type":"article","venue":"JCI Insight","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Liminal BioSciences (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; School of Medicine, Vanderbilt University; National Institutes of Health; Vanderbilt University; U.S. Department of Veterans Affairs","keywords":"Medicine; Kidney; Fibrosis; Albuminuria; Internal medicine; Endocrinology; Aristolochic acid; Diabetic nephropathy; Diabetes mellitus; Nephropathy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009629797,0.0003406724,0.0002954927,0.00008245389,0.000196343,0.00007360693,0.0002157896,0.0004402678,0.0001171083],"category_scores_gemma":[0.0002437503,0.0002986323,0.0000986883,0.0001607771,0.000301794,0.00002345856,0.0001736558,0.0001883107,0.00008786473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003993887,"about_ca_system_score_gemma":0.0001427421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001437148,"about_ca_topic_score_gemma":0.000005957857,"domain_scores_codex":[0.9983034,0.00008077962,0.0003092948,0.0006785791,0.0001819892,0.0004459736],"domain_scores_gemma":[0.998809,0.000012188,0.0001359113,0.0004704618,0.0001868403,0.0003855319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006477199,0.00006462339,0.001508391,0.00002461688,0.0001094814,6.37027e-7,0.0001348336,3.500174e-7,0.9849793,0.0000212321,0.01088218,0.001626575],"study_design_scores_gemma":[0.001686621,0.0008442743,0.0003451186,0.00002843861,0.00002189004,0.000009785696,0.00001921435,0.00005381989,0.8607215,0.00002268078,0.1359047,0.0003419878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963055,0.0008560115,0.0005082756,0.0004000993,0.0006145574,0.0003589218,0.0001168774,0.00006270062,0.0007770213],"genre_scores_gemma":[0.9953189,0.0001890203,0.00103611,0.001748518,0.001124433,0.00005956828,0.0001312785,0.00006266128,0.0003295518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1250225,"threshold_uncertainty_score":0.9999466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005861098677137753,"score_gpt":0.2179968912578717,"score_spread":0.212135792580734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}