{"id":"W2803747889","doi":"10.1002/ijc.31586","title":"<scp>S</scp>erum‐derived carcinoembryonic antigen (<scp>CEA</scp>) activates fibroblasts to induce a local re‐modeling of the extracellular matrix that favors the engraftment of <scp>CEA</scp>‐expressing tumor cells","year":2018,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research; Ontario Institute for Cancer Research; Canadian Cancer Society","keywords":"Carcinoembryonic antigen; Extracellular matrix; Cancer research; Fibronectin; Metastasis; Fibroblast; Cancer; Biology; Pathology; Immunology; Chemistry; Medicine; Cell biology; Cell culture; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009222121,0.0002782627,0.00009899751,0.0002284418,0.0001007162,0.0001518629,0.00008434495,0.000219871,0.002277134],"category_scores_gemma":[0.0000816294,0.00007401904,0.0002285315,0.0001157332,0.0001359655,0.00008077754,0.0001184798,0.000319231,0.0003899305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146582,"about_ca_system_score_gemma":0.0001678317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006875648,"about_ca_topic_score_gemma":0.001520653,"domain_scores_codex":[0.999904,0.00001723133,0.000006270449,0.00002084057,0.00002455811,0.00002703905],"domain_scores_gemma":[0.999958,0.000009936262,0.000007454063,0.000005252166,0.000006778056,0.00001242603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002831051,0.00001439332,0.0001440781,0.00002225547,0.000003518628,0.00002975289,0.000002956591,0.00001766301,0.9985881,0.00005712781,0.00004755637,0.001044074],"study_design_scores_gemma":[0.00001502428,0.0002781315,0.008582618,0.000008170124,0.00001298071,0.000605654,0.00001344038,0.0005526224,0.9858348,0.00003565906,0.004058329,0.000002689328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869013,0.002197949,0.004184518,0.0001525449,0.00003580105,0.00005194234,0.0003480866,0.00008152668,0.006046313],"genre_scores_gemma":[0.9873468,0.001321594,0.004841488,0.00008655536,0.00002574766,0.00005336871,0.0009305694,0.00001589894,0.005378029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002277134,"threshold_uncertainty_score":0.007617772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03181108160697788,"score_gpt":0.3289172101404089,"score_spread":0.297106128533431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}