{"id":"W2803757730","doi":"10.1016/j.colsurfb.2018.05.019","title":"Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers?","year":2018,"lang":"en","type":"article","venue":"Colloids and Surfaces B Biointerfaces","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Fundação para a Ciência e a Tecnologia; Fundação de Amparo à Pesquisa do Estado de São Paulo; Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR; Conselho Nacional de Desenvolvimento Científico e Tecnológico; European Commission","keywords":"Chemistry; Lipid bilayer; Bilayer; Indometacin; Phospholipid; Antiinflammatory drug; Pharmacology; Moiety; Membrane; Drug; Liposome; Biophysics; Nonsteroidal; Biochemistry; Stereochemistry; In vitro; Enzyme inhibitor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002962702,0.0002601202,0.0004126698,0.0001033518,0.0001777123,0.000297779,0.0003570629,0.0007613182,0.001303309],"category_scores_gemma":[0.0004497686,0.0001150808,0.0002847011,0.00006625061,0.0004165104,0.0006861048,0.0002047075,0.0004553029,0.0003163419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614448,"about_ca_system_score_gemma":0.0002819486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000383467,"about_ca_topic_score_gemma":0.0009575024,"domain_scores_codex":[0.9998664,0.00003819792,0.00001140711,0.00001313602,0.0000243271,0.00004652773],"domain_scores_gemma":[0.9998573,0.00003344697,0.00004485878,0.00001380319,0.00002448961,0.00002613961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004505334,0.000349689,0.002531804,0.001284448,0.000112337,0.0007969287,0.00009319381,0.0001314803,0.9399753,0.001006872,0.001049156,0.04816348],"study_design_scores_gemma":[0.0005238052,0.006713215,0.0232957,0.0001735043,0.0003525563,0.002317389,0.0005048328,0.001261997,0.9305368,0.000906313,0.03337375,0.00004012798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9128445,0.07536542,0.002233546,0.004538096,0.0008984979,0.00009607009,0.0001334619,0.00008891872,0.003801496],"genre_scores_gemma":[0.9753135,0.02070732,0.0009711719,0.0004233429,0.0001847869,0.00002869311,0.00006573083,0.000008281257,0.002297312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303309,"threshold_uncertainty_score":0.00436002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009948599799528121,"score_gpt":0.2533951907344131,"score_spread":0.243446590934885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}