{"id":"W2803782032","doi":"10.1242/jcs.217398","title":"Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex","year":2018,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Cambridge Institute for Medical Research, University of Cambridge; China Scholarship Council; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Retromer; Function (biology); Cell biology; Endosome; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117262,0.0003794093,0.0002621466,0.0002601825,0.0001954798,0.0003111704,0.0003504224,0.0002899698,0.001781045],"category_scores_gemma":[0.0001024822,0.0000913641,0.0002998464,0.0001722402,0.000248129,0.0001697246,0.0002329301,0.0006239414,0.0003927175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000547775,"about_ca_system_score_gemma":0.0003066948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001175157,"about_ca_topic_score_gemma":0.001435037,"domain_scores_codex":[0.9998448,0.00001913147,0.00001706081,0.000024808,0.0000343813,0.00005982388],"domain_scores_gemma":[0.9999338,0.00001241817,0.00001120436,0.000009416212,0.000006979606,0.00002606424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002242702,0.00005490629,0.0001226145,0.0000521268,0.000009226813,0.00005460347,0.000008995866,0.0001096292,0.9978703,0.0002683336,0.0000828413,0.001142062],"study_design_scores_gemma":[0.00001535074,0.0001401511,0.0006500149,0.000003335753,0.00001401692,0.00006320474,0.00001004175,0.0007578806,0.9963304,0.00002689064,0.001986322,0.000002430293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916155,0.002700509,0.001691655,0.0002193004,0.00008748471,0.00002815598,0.000387731,0.00008059054,0.003189105],"genre_scores_gemma":[0.9965359,0.0006956533,0.0006741017,0.00004781348,0.000006493142,0.00002596182,0.0004238649,0.00001145478,0.001578863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001781045,"threshold_uncertainty_score":0.0059582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007400546266948344,"score_gpt":0.221124521022603,"score_spread":0.2137239747556547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}