{"id":"W2803782032","doi":"10.1242/jcs.217398","title":"Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex","year":2018,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Cambridge Institute for Medical Research, University of Cambridge; China Scholarship Council; Medical Research Council Canada; Wellcome Trust","keywords":"Biology; Retromer; Function (biology); Cell biology; Endosome; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003980974,0.00004589445,0.0000732342,0.00002784574,0.000109186,0.000007434546,0.0001251576,0.00003083416,0.000007967378],"category_scores_gemma":[0.00003008331,0.00002563585,0.00004630594,0.0001935882,0.0006426427,0.000009759532,0.00002286557,0.00006542268,9.770577e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001020239,"about_ca_system_score_gemma":0.0001024906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001640482,"about_ca_topic_score_gemma":0.00004803938,"domain_scores_codex":[0.9994403,0.0000287407,0.0001637603,0.00008482503,0.0002029866,0.00007944295],"domain_scores_gemma":[0.9992459,0.000007985563,0.000283038,0.0001027078,0.0003354455,0.00002492261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006828346,0.0000154986,0.001927735,0.000005878728,0.000004762445,8.940068e-8,0.0002442561,0.000005205693,0.9974148,0.00001719602,0.00002810178,0.0002681416],"study_design_scores_gemma":[0.000124719,0.0003790861,0.05994828,0.00001480661,0.00001445346,0.000005978713,0.0001367855,0.00002354087,0.9384473,0.0001105545,0.0007657683,0.00002870604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967482,0.0001215684,0.002316123,0.0001159773,0.0001106715,0.00005235337,0.000002064813,4.221869e-7,0.0005325959],"genre_scores_gemma":[0.9996797,0.00006448665,0.00007362023,0.00004255971,0.00008563963,3.10147e-7,0.000002615343,0.000002336564,0.00004874856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05896753,"threshold_uncertainty_score":0.2367844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007400546266948344,"score_gpt":0.221124521022603,"score_spread":0.2137239747556547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}