{"id":"W2803809638","doi":"10.1186/s12934-018-0916-9","title":"Identification, function, and application of 3-ketosteroid Δ1-dehydrogenase isozymes in Mycobacterium neoaurum DSM 1381 for the production of steroidic synthons","year":2018,"lang":"en","type":"article","venue":"Microbial Cell Factories","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Natural Science Foundation of China","keywords":"Ketosteroid; Synthon; Isozyme; Identification (biology); Mycobacterium; Function (biology); Biology; Computational biology; Microbiology; Chemistry; Biochemistry; Enzyme; Genetics; Stereochemistry; Bacteria; Botany","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135322,0.0001433813,0.0001417673,0.00002395548,0.0000953889,0.00001796274,0.0001510464,0.0001423659,0.000005535558],"category_scores_gemma":[0.00007210935,0.0001218844,0.00005560078,0.0001003073,0.0002934436,0.000009708094,0.00006586411,0.00005193776,8.786798e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001104858,"about_ca_system_score_gemma":0.00004057702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001432674,"about_ca_topic_score_gemma":0.00003797959,"domain_scores_codex":[0.9990853,0.00002205804,0.0003436005,0.0003356753,0.000066407,0.0001469687],"domain_scores_gemma":[0.9991107,0.00002530175,0.0002319325,0.0003840692,0.0002204215,0.00002756958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002642151,0.00006734046,0.003055204,0.0002153395,0.00002583667,2.718126e-8,0.0001590884,0.00000242132,0.995109,0.000003335853,0.0008467551,0.000251464],"study_design_scores_gemma":[0.0002662998,0.0001274013,0.002554572,0.00001787658,0.00003988577,0.000004489183,0.0002687626,0.000006286636,0.9910159,0.00003072645,0.00555112,0.0001167121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961404,0.0008329587,0.002143396,0.0001079139,0.0003242063,0.0003279083,0.00009917864,0.000006760697,0.00001729829],"genre_scores_gemma":[0.998755,0.00009899557,0.00005462751,0.00002163095,0.0003909517,0.00004516828,0.0001620634,0.00001435463,0.0004572451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004704365,"threshold_uncertainty_score":0.4970302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004907078831975833,"score_gpt":0.2115430449907704,"score_spread":0.2066359661587945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}