{"id":"W2803826590","doi":"10.3390/v10050258","title":"CRISPR/Cas9 Mutagenesis of UL21 in Multiple Strains of Herpes Simplex Virus Reveals Differential Requirements for pUL21 in Viral Replication","year":2018,"lang":"en","type":"article","venue":"Viruses","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"CRISPR; Biology; Herpes simplex virus; Mutagenesis; Viral replication; Virology; Cas9; Virus; Strain (injury); Cell; Genetics; Phenotype; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004694622,0.0005104114,0.000638939,0.0004758044,0.0003091065,0.0009951128,0.0005329407,0.0004425624,0.001440896],"category_scores_gemma":[0.0004085168,0.0002631141,0.0005354051,0.0003303706,0.0004006458,0.0004536261,0.0005738335,0.001049176,0.0004429923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005621074,"about_ca_system_score_gemma":0.0004296176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007372255,"about_ca_topic_score_gemma":0.00184294,"domain_scores_codex":[0.9993885,0.00006335993,0.0001430662,0.0001437531,0.0001887666,0.00007260075],"domain_scores_gemma":[0.9995456,0.0001455465,0.0001024013,0.0001068239,0.00004134552,0.00005824239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006726445,0.00001860764,0.0003499914,0.00003566159,0.00001014078,0.00006224844,0.00001620577,0.000131355,0.9973292,0.0001620745,0.00002631071,0.001790912],"study_design_scores_gemma":[0.000003775572,0.00006913589,0.001678198,0.000005063556,0.00001668301,0.0002357008,0.00002162176,0.0008571182,0.9957688,0.00006431667,0.001272782,0.000006723012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739473,0.001414015,0.02021934,0.0001376923,0.00009978969,0.0001066808,0.001151171,0.0003657096,0.002558335],"genre_scores_gemma":[0.9791427,0.0006533249,0.01663384,0.00007208771,0.00000804875,0.00006200206,0.000987774,0.0001344379,0.002305786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440896,"threshold_uncertainty_score":0.004820228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1065952682050303,"score_gpt":0.3890313555102253,"score_spread":0.2824360873051949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}