{"id":"W2803870016","doi":"10.1097/qad.0000000000001882","title":"Transcriptional gene silencing limits CXCR4-associated depletion of bone marrow CD34+ cells in HIV-1 infection","year":2018,"lang":"en","type":"article","venue":"AIDS","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Gene silencing; Bone marrow; Human immunodeficiency virus (HIV); CD34; CXCR4; Virology; Biology; Lentivirus; Gene; Immunology; Viral disease; Cell biology; Genetics; Stem cell; Inflammation; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001874768,0.0002032695,0.0002215718,0.0001772337,0.0001225151,0.0003754145,0.0002431754,0.0002390009,0.001179577],"category_scores_gemma":[0.0001342439,0.0001175348,0.0001467626,0.00009949037,0.0002372328,0.0001487238,0.0002013884,0.0005259695,0.0002519507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001829007,"about_ca_system_score_gemma":0.0002190409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003362888,"about_ca_topic_score_gemma":0.0005533189,"domain_scores_codex":[0.9998621,0.00002392658,0.00001396464,0.00002741433,0.00003820212,0.00003434581],"domain_scores_gemma":[0.9999127,0.00001562358,0.00003122373,0.00001129967,0.000008606688,0.00002056215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000058809,0.00004373436,0.0001672224,0.00002769306,0.000002732923,0.00001466521,0.000009746996,0.00006227934,0.9981602,0.0001171937,0.00003265306,0.001303065],"study_design_scores_gemma":[0.00002732727,0.0005143486,0.00289778,0.00001186427,0.00002287067,0.0001619703,0.00001810565,0.001423698,0.9927994,0.00004852546,0.002070889,0.000003327309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946893,0.001616681,0.00232278,0.00006801056,0.00001684049,0.00004670211,0.0001957932,0.00007376733,0.00097007],"genre_scores_gemma":[0.9954723,0.0007664966,0.001972069,0.00004231446,0.000007489175,0.00004185819,0.0003254504,0.00001385787,0.001358125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001179577,"threshold_uncertainty_score":0.003946066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650166587615815,"score_gpt":0.2456586837195701,"score_spread":0.2291570178434119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}