{"id":"W2803870016","doi":"10.1097/qad.0000000000001882","title":"Transcriptional gene silencing limits CXCR4-associated depletion of bone marrow CD34+ cells in HIV-1 infection","year":2018,"lang":"en","type":"article","venue":"AIDS","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Gene silencing; Bone marrow; Human immunodeficiency virus (HIV); CD34; CXCR4; Virology; Biology; Lentivirus; Gene; Immunology; Viral disease; Cell biology; Genetics; Stem cell; Inflammation; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002479788,0.00008992486,0.0001687001,0.0001696943,0.00007658177,0.000005161574,0.00004444934,0.0001586043,0.0006760543],"category_scores_gemma":[0.00004944001,0.00008388481,0.00006468291,0.0001965091,0.0001198577,0.00008538115,0.00001249533,0.0001358289,0.001025361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009863159,"about_ca_system_score_gemma":0.00005181826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005210774,"about_ca_topic_score_gemma":0.0003591155,"domain_scores_codex":[0.99914,0.0001770665,0.000212917,0.0001656625,0.00004671673,0.0002575939],"domain_scores_gemma":[0.9996756,0.00005841914,0.00005730883,0.0001043117,0.00008559723,0.0000187167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084266,0.0002887135,0.06453092,0.000008083105,0.00008533714,0.00000422469,0.0003012119,0.000004345937,0.9313623,0.00007936605,0.0007040253,0.002523045],"study_design_scores_gemma":[0.001826235,0.0008090491,0.2931629,0.00003384814,0.00001866666,0.000009259326,0.00003385366,0.000006731478,0.7027587,0.00006841939,0.001193144,0.00007911972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980954,0.0004263325,0.0002898908,0.00006245314,0.0002640871,0.0001395456,0.00008923883,0.00002698514,0.0006060835],"genre_scores_gemma":[0.9984882,0.0001037409,0.0001026621,0.00002649614,0.00002732102,0.00001870581,0.0003532032,0.000008103983,0.0008716005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.228632,"threshold_uncertainty_score":0.9997525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650166587615815,"score_gpt":0.2456586837195701,"score_spread":0.2291570178434119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}