{"id":"W2803873510","doi":"10.17863/cam.18662","title":"Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.","year":2018,"lang":"en","type":"article","venue":"UWA Profiles and Research Repository (University of Western Australia)","topic":"Diet and metabolism studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"FP7 Ideas: European Research Council; Carolina Population Center, University of North Carolina at Chapel Hill; National Center for Research Resources; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute on Aging; NIHR Cambridge Biomedical Research Centre; National Health and Medical Research Council; Canadian Institutes of Health Research; Forsknings- og Innovationsstyrelsen; National Heart, Lung, and Blood Institute; Kaiser Foundation Research Institute; Directorate for Biological Sciences; National Institutes of Health; Diabetesforeningen; MRC-PHE Centre for Environment and Health; Centre for Cognitive Ageing and Cognitive Epidemiology; H. Lundbeck A/S; Hjartavernd; Institut de Cardiologie de Montréal; Medical Research Council; Servier; Regione Lombardia; Boehringer Ingelheim Stiftung; National Center for Advancing Translational Sciences; Università degli Studi di Verona; Fondation Leenaards; Danish Agency for Science and Higher Education; Marcus och Amalia Wallenbergs minnesfond; Högskolan Dalarna; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Sydäntutkimussäätiö; Universitetet i Bergen; University of Minnesota; Vetenskapsrådet; Aarhus Universitets Forskningsfond; Max-Planck-Gesellschaft; National Institute of Diabetes and Digestive and Kidney Diseases; Norwegian Institute of Public Health; Knut och Alice Wallenbergs Stiftelse; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Region Hovedstaden; Novo Nordisk; Hjärt-Lungfonden; British Heart Foundation; Bundesministerium für Bildung und Forschung; Strategiske Forskningsråd; ZonMw; SystemsX.ch; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Foundation for the Study of Diabetes; Cancer Research UK; National University of Singapore; Landstinget Dalarnas; AstraZeneca; National Institute for Health Research Health Protection Research Unit; European Commission; Imperial College Healthcare NHS Trust; Wellcome Trust; Aarhus Universitet; Australian Government; Norges Forskningsråd; QIMR Berghofer Medical Research Institute; Norges Teknisk-Naturvitenskapelige Universitet; Wake Forest School of Medicine; Helse Vest; Sundhed og Sygdom, Det Frie Forskningsråd; Johns Hopkins University; National Cancer Institute; Lundbeckfonden; Foundation for Cardiovascular Research; National Science Foundation; Massachusetts General Hospital; Erasmus Medisch Centrum; Diabetesforbundet; Pfizer; Fondation Institut de Cardiologie de Montréal; Northwestern University; Queen Mary University of London; National Institute for Health and Care Research; Istituto Superiore di Sanità; Imperial College London; Eunice Kennedy Shriver National Institute of Child Health and Human Development; GlaxoSmithKline; Andrea and Charles Bronfman Philanthropies; American Heart Association","keywords":"Body mass index; Energy expenditure; Obesity; Energy metabolism; Index (typography); Endocrinology; Biology; Medicine; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003293429,0.0006343581,0.0003829788,0.0006969346,0.0005086593,0.0006861584,0.0003499076,0.0007430164,0.005623478],"category_scores_gemma":[0.001790529,0.0002167961,0.000491244,0.001433757,0.0003349629,0.0002655851,0.0003311448,0.0008578896,0.0005014211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001951394,"about_ca_system_score_gemma":0.0002716548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007087497,"about_ca_topic_score_gemma":0.009752992,"domain_scores_codex":[0.999685,0.00008874505,0.0000345062,0.00008841055,0.00005860144,0.00004466265],"domain_scores_gemma":[0.9992785,0.0002179764,0.0003054597,0.00006896076,0.00005439296,0.00007466497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007987419,0.0004113032,0.8414991,0.0004743271,0.002492258,0.003384244,0.0009691646,0.0007794998,0.09099607,0.003495637,0.006482718,0.04102832],"study_design_scores_gemma":[0.00009174348,0.0001402883,0.9902955,0.00007209273,0.0006715404,0.001244987,0.0001015017,0.0004788004,0.002712213,0.00162657,0.00254996,0.00001489346],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846977,0.003070312,0.001906239,0.0009552489,0.0001367349,0.00002863518,0.004859727,0.00008151619,0.00426387],"genre_scores_gemma":[0.9934561,0.0009135244,0.001639272,0.0002661576,0.0000638674,0.00002328977,0.001892682,0.00004854515,0.001696583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007087497,"threshold_uncertainty_score":0.01881242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05511221701567106,"score_gpt":0.2864590713623408,"score_spread":0.2313468543466697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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